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Diagnostic and typing options for investigating diseases associated with Pasteurella multocida.

Dziva, F, Muhairwa, AP, Bisgaard, M and Christensen, H (2008) Diagnostic and typing options for investigating diseases associated with Pasteurella multocida. Vet Microbiol, 128 (1-2). pp. 1-22.

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Pasteurella multocida is responsible for major animal diseases of economic significance in both developed and developing countries whereas human infections related to this bacterium are infrequent. Significantly, development of a carrier status or latent infections plays a critical role in the epidemiology of these diseases. Aiming at increased knowledge of these infections, we examine potential diagnostic and selected typing systems for investigating diseases caused by P. multocida. Detection of P. multocida from clinical specimen by; (i) isolation and identification, (ii) polymerase chain reaction (PCR), iii) specific hybridisation probes, (iv) serological tests and (v) other alternative methods is critically evaluated. These detection systems provide a wide spectrum of options for rapid diagnosis and for detecting and understanding of latent infections in herd/flock health control programmes, though PCR methods for detecting P. multocida in clinical specimen appear increasingly preferred. For establishing the clonality of outbreak strains, we select to discuss macromolecular profiling, serotyping, biotyping, restriction enzyme analysis, ribotyping and multiplex PCR typing. Although P. multocida infections can be rapidly diagnosed with molecular and serological tests, isolation and accurate species identification are central to epidemiological tracing of outbreak strains. Our review brings together comprehensive and essential information that may be adapted for confirming diagnosis and determining the molecular epidemiology of diseases associated with P. multocida.

Item Type: Article
Divisions : Surrey research (other units)
Authors :
Muhairwa, AP
Bisgaard, M
Christensen, H
Date : 1 April 2008
DOI : 10.1016/j.vetmic.2007.10.018
Uncontrolled Keywords : Animals, Antibodies, Bacterial, Bacterial Typing Techniques, Bacteriological Techniques, DNA, Bacterial, Enzyme-Linked Immunosorbent Assay, Genetic Techniques, Genotype, Host-Pathogen Interactions, Pasteurella Infections, Pasteurella multocida, Phenotype, Polymerase Chain Reaction
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:39
Last Modified : 24 Jan 2020 19:46

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