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The host response to lesions induced by human papillomavirus.

Stanley, M, Coleman, N and Chambers, M (1994) The host response to lesions induced by human papillomavirus. Ciba Found Symp, 187. pp. 21-32.

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Abstract

Human papillomaviruses (HPVs) are strictly intraepithelial pathogens: in the natural productive infection they induce benign epithelial proliferations of mucocutaneous surfaces, some of which may progress to malignancy. Benign HPV-induced lesions are chronic persistent growths; high levels of viral antigen are expressed in the apparent absence of a host immune response suggesting that these viruses have evolved efficient mechanisms of immune evasion. Cell-mediated responses are central in the pathogenesis of HPV and regression of both cutaneous and genital warts histologically resembles a delayed-type hypersensitivity response (DTH). The antigen(s) in the wart against which this response is initiated are not known but in an experimental murine model DTH responses to the E6 and E7 proteins of HPV-16 can be elicited when viral antigen is presented via the epithelial route. Priming with low levels of viral antigen in this model induces non-responsiveness and the loss of DTH. In HPV-associated cancers the E6/E7 genes are expressed and an antibody response to the proteins is found in at least 50% of cases indicating that these oncoproteins are potential targets for immunotherapy.

Item Type: Article
Authors :
NameEmailORCID
Stanley, MUNSPECIFIEDUNSPECIFIED
Coleman, NUNSPECIFIEDUNSPECIFIED
Chambers, Mm.chambers@surrey.ac.ukUNSPECIFIED
Date : 1994
Uncontrolled Keywords : Animals, Antibody Formation, Antigens, Viral, Condylomata Acuminata, Humans, Hypersensitivity, Delayed, Immunohistochemistry, In Situ Hybridization, Keratinocytes, Mice, Oncogene Proteins, Viral, Papillomaviridae, Papillomavirus Infections, Tumor Virus Infections
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:39
Last Modified : 17 May 2017 14:51
URI: http://epubs.surrey.ac.uk/id/eprint/828632

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