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EN2 in Prostate Cancer.

McGrath, SE, Michael, A, Morgan, R and Pandha, H (2015) EN2 in Prostate Cancer. Adv Clin Chem, 71. pp. 47-76.

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Abstract

Despite extensive efforts to identify a clinically useful diagnostic biomarker in prostate cancer, no new test has been approved by regulatory authorities. As a result, this unmet need has shifted to biomarkers that additionally indicate presence or absence of "significant" disease. EN2 is a homeodomain-containing transcription factor secreted by prostate cancer into the urine and can be detected by enzyme-linked immunoassay. EN2 may be an ideal biomarker because normal prostate tissue and benign prostatic hypertrophic cells do not secrete EN2. This review discusses the enormous potential of EN2 to address this unmet need and provide the urologist with a simple, inexpensive, and reliable prostate cancer biomarker.

Item Type: Article
Authors :
NameEmailORCID
McGrath, SEUNSPECIFIEDUNSPECIFIED
Michael, Aa.michael@surrey.ac.ukUNSPECIFIED
Morgan, RUNSPECIFIEDUNSPECIFIED
Pandha, Hh.pandha@surrey.ac.ukUNSPECIFIED
Date : 2015
Identification Number : 10.1016/bs.acc.2015.06.002
Uncontrolled Keywords : Biomarker, Engrailed 2, Prostate cancer, Significant disease, Biomarkers, Tumor, Homeodomain Proteins, Humans, Male, Nerve Tissue Proteins, Prostatic Neoplasms, Risk Factors
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:34
Last Modified : 17 May 2017 14:50
URI: http://epubs.surrey.ac.uk/id/eprint/828341

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