University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Confirmed infection with intestinal schistosomiasis in semi-captive wild-born chimpanzees on Ngamba Island, Uganda.

Standley, CJ, Mugisha, L, Verweij, JJ, Adriko, M, Arinaitwe, M, Rowell, C, Atuhaire, A, Betson, M, Hobbs, E, van Tulleken, CR, Kane, RA, van Lieshout, L, Ajarova, L, Kabatereine, NB and Stothard, JR (2011) Confirmed infection with intestinal schistosomiasis in semi-captive wild-born chimpanzees on Ngamba Island, Uganda. Vector Borne Zoonotic Dis, 11 (2). pp. 169-176.

Full text not available from this repository.

Abstract

BACKGROUND: Intestinal schistosomiasis, caused by Schistosoma mansoni, is endemic to Lake Victoria, with high prevalence of the disease observed in human lakeshore communities. However, nonhuman primates have recently been overlooked as potential hosts of the disease, despite known susceptibility. METHODS: Using a variety of stool, urine, and serological diagnostic methods, 39 semi-captive wild-born chimpanzees and 37 staff members at Ngamba Island Chimpanzee Sanctuary, Lake Victoria, Uganda, were examined for S. mansoni infection. Miracidia recovered from stool were DNA barcoded to investigate cross-over between humans and chimpanzees. The island was also surveyed for Biomphalaria intermediate host snails, which were examined for infection with S. mansoni. RESULTS: Chimpanzees were unequivocally shown to be infected with intestinal schistosomiasis with a seroprevalence in excess of 90%. Three egg-positive cases were detected, although the sensitivity of the diagnostic tests varied due to earlier prophylactic praziquantel treatment. Miracidia hatched from chimpanzee stool revealed three DNA haplotypes commonly found in humans living throughout Lake Victoria, including staff on Ngamba Island, as well as two novel haplotypes. At one site, a snail was observed shedding schistosome cercariae. CONCLUSIONS: The anthropozoonotic potential of intestinal schistosomiasis on Ngamba Island is greater than previously thought. Moreover, the ability of chimpanzees to void schistosome eggs capable of hatching into viable miracidia further suggests that these nonhuman primates may be capable of maintaining a local zoonotic transmission of schistosomiasis independently of humans. The implications for management of captive and wild primate populations at risk of exposure are discussed.

Item Type: Article
Authors :
NameEmailORCID
Standley, CJUNSPECIFIEDUNSPECIFIED
Mugisha, LUNSPECIFIEDUNSPECIFIED
Verweij, JJUNSPECIFIEDUNSPECIFIED
Adriko, MUNSPECIFIEDUNSPECIFIED
Arinaitwe, MUNSPECIFIEDUNSPECIFIED
Rowell, CUNSPECIFIEDUNSPECIFIED
Atuhaire, AUNSPECIFIEDUNSPECIFIED
Betson, Mm.betson@surrey.ac.ukUNSPECIFIED
Hobbs, EUNSPECIFIEDUNSPECIFIED
van Tulleken, CRUNSPECIFIEDUNSPECIFIED
Kane, RAUNSPECIFIEDUNSPECIFIED
van Lieshout, LUNSPECIFIEDUNSPECIFIED
Ajarova, LUNSPECIFIEDUNSPECIFIED
Kabatereine, NBUNSPECIFIEDUNSPECIFIED
Stothard, JRUNSPECIFIEDUNSPECIFIED
Date : February 2011
Identification Number : https://doi.org/10.1089/vbz.2010.0156
Uncontrolled Keywords : Animals, Ape Diseases, Feces, Genotype, Geography, Humans, Molecular Sequence Data, Pan troglodytes, Prevalence, Schistosoma mansoni, Schistosomiasis mansoni, Snails, Uganda
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:33
Last Modified : 17 May 2017 14:50
URI: http://epubs.surrey.ac.uk/id/eprint/828284

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800