University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Intestinal schistosomiasis in chimpanzees on Ngamba Island, Uganda: observations on liver fibrosis, schistosome genetic diversity and praziquantel treatment.

Standley, CJ, Mugisha, L, Adriko, M, Arinaitwe, M, Rukundo, J, Ajarova, L, Mopya, S, Betson, M, Kabatereine, NB and Stothard, JR (2013) Intestinal schistosomiasis in chimpanzees on Ngamba Island, Uganda: observations on liver fibrosis, schistosome genetic diversity and praziquantel treatment. Parasitology, 140 (3). pp. 285-295.

Full text not available from this repository.

Abstract

Despite treatment with praziquantel (PZQ) at 40 mg/kg in food, several chimpanzees on Ngamba Island Chimpanzee Sanctuary (NICS) continue to excrete eggs of Schistosoma mansoni. To monitor disease, 8 animals were closely examined under anaesthesia in March 2011 with portable ultrasonography and by rectal snip biopsy. Schistosome genetic diversity had been previously assayed within 4 of these chimpanzees, finding extensive diversity with 27 DNA barcodes encountered, although none was common to all animals. Calcified schistosome eggs were found in the rectal snips from 5 chimpanzees and liver fibrosis was clearly documented, indicative of progressive disease in 6 animals, the latter being surprisingly advanced in a younger chimpanzee. All 8 animals were treated under anaesthesia by oral gavage with PZQ at 60 mg/kg dosing that was well tolerated. These animals were again re-examined in June 2012 using stool and urine sampling. Only 1 chimpanzee appeared to be free from infection and active egg excretion was confirmed in 6 animals. If intestinal schistosomiasis is to be controlled within this setting, a long-term disease management plan is required which should combine active case-detection with an insistent treatment regime with praziquantel for these chimpanzees, exploring perhaps the performance of even higher dosing.

Item Type: Article
Authors :
NameEmailORCID
Standley, CJUNSPECIFIEDUNSPECIFIED
Mugisha, LUNSPECIFIEDUNSPECIFIED
Adriko, MUNSPECIFIEDUNSPECIFIED
Arinaitwe, MUNSPECIFIEDUNSPECIFIED
Rukundo, JUNSPECIFIEDUNSPECIFIED
Ajarova, LUNSPECIFIEDUNSPECIFIED
Mopya, SUNSPECIFIEDUNSPECIFIED
Betson, Mm.betson@surrey.ac.ukUNSPECIFIED
Kabatereine, NBUNSPECIFIEDUNSPECIFIED
Stothard, JRUNSPECIFIEDUNSPECIFIED
Date : March 2013
Identification Number : 10.1017/S0031182012001576
Uncontrolled Keywords : Animals, Anthelmintics, Ape Diseases, DNA Barcoding, Taxonomic, Feces, Female, Genetic Variation, Humans, Liver Cirrhosis, Male, Pan troglodytes, Parasite Egg Count, Praziquantel, Schistosoma mansoni, Schistosomiasis mansoni, Treatment Outcome, Uganda, Urine
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:33
Last Modified : 17 May 2017 14:50
URI: http://epubs.surrey.ac.uk/id/eprint/828275

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800