University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Transfusion-transmitted malaria in Ghana.

Owusu-Ofori, AK, Betson, M, Parry, CM, Stothard, JR and Bates, I (2013) Transfusion-transmitted malaria in Ghana. Clin Infect Dis, 56 (12). pp. 1735-1741.

Full text not available from this repository.


BACKGROUND: In sub-Saharan Africa, the prevalence of malaria parasitemia in blood donors varies from 0.6% to 50%. Although the burden of TTM in malaria-endemic countries is unknown, it is recommended that all donated blood is screened for malaria parasites. This study aimed to establish the incidence of TTM and identify a suitable screening test. METHODS: Pregnant women, children, and immunocompromised malaria-negative transfusion recipients in a teaching hospital in Ghana were recruited over the course of 1 year. Parasites detected in recipients within 14 days of the transfusion were genotyped and compared to parasites in the transfused blood. The presence of genotypically identical parasites in the recipient and the transfused blood confirmed transfusion-transmitted malaria. Four malaria screening tests were compared to assess their usefulness in the context of African blood banks. RESULTS: Of the 50 patients who received transfusions that were positive for Plasmodium falciparum by polymerase chain reaction (PCR), 7 recipients developed PCR-detectable parasitemia. In only 1 of the 50 recipients (2%) was the parasite identical to that in the transfused blood. The prevalence of P. falciparum malaria in transfused blood was 4.7% (21/445) by microscopy, 13.7% (60/440) by rapid diagnostic test, 18% (78/436) by PCR, and 22.2% (98/442) by enzyme immunoassay. CONCLUSIONS: Although malaria parasites are commonly detected in blood donors in malaria-endemic areas, transfusion-transmitted malaria occurs infrequently. Policies recommend screening blood donors for malaria, but none of the commonly used methods is sufficiently sensitive to be used by blood banks in malaria-endemic countries.

Item Type: Article
Divisions : Surrey research (other units)
Authors :
Owusu-Ofori, AK
Parry, CM
Stothard, JR
Bates, I
Date : June 2013
DOI : 10.1093/cid/cit130
Uncontrolled Keywords : Plasmodium falciparum, Transfusion-transmitted malaria, blood donor, blood transfusion, screening, Adolescent, Adult, Blood Donors, Blood Transfusion, Child, Child, Preschool, Cohort Studies, Endemic Diseases, Female, Ghana, Humans, Immunoassay, Incidence, Infant, Malaria, Male, Mass Screening, Microscopy, Middle Aged, Parasitemia, Parasitology, Polymerase Chain Reaction, Pregnancy
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:33
Last Modified : 24 Jan 2020 19:34

Actions (login required)

View Item View Item


Downloads per month over past year

Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800