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Natural-cause mortality and long-term exposure to particle components: An Analysis of 19 European cohorts within the multi-center ESCAPE project

Beelen, R, Hoek, G, Raaschou-Nielsen, O, Stafoggia, M, Andersen, ZJ, Weinmayr, G, Hoffmann, B, Wolf, K, Samoli, E, Fischer, PH , Nieuwenhuijsen, MJ, Xun, WW, Katsouyanni, K, Dimakopoulou, K, Marcon, A, Vartiainen, E, Lanki, T, Yli-Tuomi, T, Oftedal, B, Schwarze, PE, Nafstad, P, de Faire, U, Pedersen, NL, Östenson, CG, Fratiglioni, L, Penell, J, Korek, M, Pershagen, G, Eriksen, KT, Overvad, K, Sørensen, M, Eeftens, M, Peeters, PH, Meliefste, K, Wang, M, Bas Bueno-De-Mesquita, H, Sugiri, D, Krämer, U, Heinrich, J, De Hoogh, K, Key, T, Peters, A, Hampel, R, Concin, H, Nagel, G, Jaensch, A, Ineichen, A, Tsai, MY, Schaffner, E, Probst-Hensch, NM, Schindler, C, Ragettli, MS, Vilier, A, Clavel-Chapelon, F, Declercq, C, Ricceri, F, Sacerdote, C, Galassi, C, Migliore, E, Ranzi, A, Cesaroni, G, Badaloni, C, Forastiere, F, Katsoulis, M, Trichopoulou, A, Keuken, M, Jedynska, A, Kooter, IM, Kukkonen, J, Sokhi, RS, Vineis, P and Brunekreef, B (2015) Natural-cause mortality and long-term exposure to particle components: An Analysis of 19 European cohorts within the multi-center ESCAPE project Environmental Health Perspectives, 123 (6). pp. 525-533.

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Abstract

© 2015, Public Health Services, US Dept of Health and Human Services. All rights reserved.Background: Studies have shown associations between mortality and long-term exposure to particulate matter air pollution. Few cohort studies have estimated the effects of the elemental composition of particulate matter on mortality. oBjectives: Our aim was to study the association between natural-cause mortality and long-term exposure to elemental components of particulate matter. Methods: Mortality and confounder data from 19 European cohort studies were used. Residential exposure to eight a priori–selected components of particulate matter (PM) was characterized following a strictly standardized protocol. Annual average concentrations of copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc within PM size fractions ≤ 2.5 μm (PM2.5) and ≤ 10 μm (PM10) were estimated using land-use regression models. Cohort-specific statistical analyses of the associations between mortality and air pollution were conducted using Cox proportional hazards models using a common protocol followed by meta-analysis. results: The total study population consisted of 291,816 participants, of whom 25,466 died from a natural cause during follow-up (average time of follow-up, 14.3 years). Hazard ratios were positive for almost all elements and statistically significant for PM2.5 sulfur (1.14; 95% CI: 1.06, 1.23 per 200 ng/m3). In a two-pollutant model, the association with PM2.5 sulfur was robust to adjustment for PM2.5 mass, whereas the association with PM2.5 mass was reduced. conclusions: Long-term exposure to PM2.5 sulfur was associated with natural-cause mortality. This association was robust to adjustment for other pollutants and PM2.5.

Item Type: Article
Authors :
NameEmailORCID
Beelen, R
Hoek, G
Raaschou-Nielsen, O
Stafoggia, M
Andersen, ZJ
Weinmayr, G
Hoffmann, B
Wolf, K
Samoli, E
Fischer, PH
Nieuwenhuijsen, MJ
Xun, WW
Katsouyanni, K
Dimakopoulou, K
Marcon, A
Vartiainen, E
Lanki, T
Yli-Tuomi, T
Oftedal, B
Schwarze, PE
Nafstad, P
de Faire, U
Pedersen, NL
Östenson, CG
Fratiglioni, L
Penell, Jj.penell@surrey.ac.uk
Korek, M
Pershagen, G
Eriksen, KT
Overvad, K
Sørensen, M
Eeftens, M
Peeters, PH
Meliefste, K
Wang, M
Bas Bueno-De-Mesquita, H
Sugiri, D
Krämer, U
Heinrich, J
De Hoogh, K
Key, T
Peters, A
Hampel, R
Concin, H
Nagel, G
Jaensch, A
Ineichen, A
Tsai, MY
Schaffner, E
Probst-Hensch, NM
Schindler, C
Ragettli, MS
Vilier, A
Clavel-Chapelon, F
Declercq, C
Ricceri, F
Sacerdote, C
Galassi, C
Migliore, E
Ranzi, A
Cesaroni, G
Badaloni, C
Forastiere, F
Katsoulis, M
Trichopoulou, A
Keuken, M
Jedynska, A
Kooter, IM
Kukkonen, J
Sokhi, RS
Vineis, P
Brunekreef, B
Date : 1 January 2015
Identification Number : 10.1289/ehp.1408095
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:32
Last Modified : 17 May 2017 10:32
URI: http://epubs.surrey.ac.uk/id/eprint/828172

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