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Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts.

Hampel, R, Peters, A, Beelen, R, Brunekreef, B, Cyrys, J, de Faire, U, de Hoogh, K, Fuks, K, Hoffmann, B, Hüls, A, Imboden, M, Jedynska, A, Kooter, I, Koenig, W, Künzli, N, Leander, K, Magnusson, P, Männistö, S, Penell, J, Pershagen, G, Phuleria, H, Probst-Hensch, N, Pundt, N, Schaffner, E, Schikowski, T, Sugiri, D, Tiittanen, P, Tsai, MY, Wang, M, Wolf, K, Lanki, T and ESCAPE TRANSPHORM study groups, (2015) Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts. Environ Int, 82. pp. 76-84.

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Abstract

BACKGROUND: Epidemiological studies have associated long-term exposure to ambient particulate matter with increased mortality from cardiovascular and respiratory disorders. Systemic inflammation is a plausible biological mechanism behind this association. However, it is unclear how the chemical composition of PM affects inflammatory responses. OBJECTIVES: To investigate the association between long-term exposure to elemental components of PM and the inflammatory blood markers high-sensitivity C-reactive protein (hsCRP) and fibrinogen as part of the European ESCAPE and TRANSPHORM multi-center projects. METHODS: In total, 21,558 hsCRP measurements and 17,428 fibrinogen measurements from cross-sections of five and four cohort studies were available, respectively. Residential long-term concentrations of particulate matter <10μm (PM10) and <2.5μm (PM2.5) in diameter and selected elemental components (copper, iron, potassium, nickel, sulfur, silicon, vanadium, zinc) were estimated based on land-use regression models. Associations between components and inflammatory markers were estimated using linear regression models for each cohort separately. Cohort-specific results were combined using random effects meta-analysis. As a sensitivity analysis the models were additionally adjusted for PM mass. RESULTS: A 5ng/m(3) increase in PM2.5 copper and a 500ng/m(3) increase in PM10 iron were associated with a 6.3% [0.7; 12.3%] and 3.6% [0.3; 7.1%] increase in hsCRP, respectively. These associations between components and fibrinogen were slightly weaker. A 10ng/m(3) increase in PM2.5 zinc was associated with a 1.2% [0.1; 2.4%] increase in fibrinogen; confidence intervals widened when additionally adjusting for PM2.5. CONCLUSIONS: Long-term exposure to transition metals within ambient particulate matter, originating from traffic and industry, may be related to chronic systemic inflammation providing a link to long-term health effects of particulate matter.

Item Type: Article
Authors :
NameEmailORCID
Hampel, RUNSPECIFIEDUNSPECIFIED
Peters, AUNSPECIFIEDUNSPECIFIED
Beelen, RUNSPECIFIEDUNSPECIFIED
Brunekreef, BUNSPECIFIEDUNSPECIFIED
Cyrys, JUNSPECIFIEDUNSPECIFIED
de Faire, UUNSPECIFIEDUNSPECIFIED
de Hoogh, KUNSPECIFIEDUNSPECIFIED
Fuks, KUNSPECIFIEDUNSPECIFIED
Hoffmann, BUNSPECIFIEDUNSPECIFIED
Hüls, AUNSPECIFIEDUNSPECIFIED
Imboden, MUNSPECIFIEDUNSPECIFIED
Jedynska, AUNSPECIFIEDUNSPECIFIED
Kooter, IUNSPECIFIEDUNSPECIFIED
Koenig, WUNSPECIFIEDUNSPECIFIED
Künzli, NUNSPECIFIEDUNSPECIFIED
Leander, KUNSPECIFIEDUNSPECIFIED
Magnusson, PUNSPECIFIEDUNSPECIFIED
Männistö, SUNSPECIFIEDUNSPECIFIED
Penell, Jj.penell@surrey.ac.ukUNSPECIFIED
Pershagen, GUNSPECIFIEDUNSPECIFIED
Phuleria, HUNSPECIFIEDUNSPECIFIED
Probst-Hensch, NUNSPECIFIEDUNSPECIFIED
Pundt, NUNSPECIFIEDUNSPECIFIED
Schaffner, EUNSPECIFIEDUNSPECIFIED
Schikowski, TUNSPECIFIEDUNSPECIFIED
Sugiri, DUNSPECIFIEDUNSPECIFIED
Tiittanen, PUNSPECIFIEDUNSPECIFIED
Tsai, MYUNSPECIFIEDUNSPECIFIED
Wang, MUNSPECIFIEDUNSPECIFIED
Wolf, KUNSPECIFIEDUNSPECIFIED
Lanki, TUNSPECIFIEDUNSPECIFIED
ESCAPE TRANSPHORM study groups, UNSPECIFIEDUNSPECIFIED
Date : September 2015
Identification Number : https://doi.org/10.1016/j.envint.2015.05.008
Uncontrolled Keywords : ESCAPE, Elemental components, Inflammation, Long-term exposure, Particulate matter, TRANSPHORM, Biomarkers, C-Reactive Protein, Cohort Studies, Copper, Environmental Exposure, Europe, Female, Fibrinogen, Humans, Inflammation, Iron, Linear Models, Models, Theoretical, Nickel, Particulate Matter, Respiratory Tract Diseases, Sulfur, Time, Vanadium, Zinc
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:32
Last Modified : 17 May 2017 10:32
URI: http://epubs.surrey.ac.uk/id/eprint/828169

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