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Clinical outcomes of first- and second-generation drug-eluting stents in patients undergoing rotational atherectomy for heavily calcified coronary lesions.

Tian, W, Mahmoudi, M, Lhermusier, T, Pendyala, LK, Kiramijyan, S, Saar, M, Ota, H, Chen, F, Torguson, R, Suddath, WO , Satler, LF, Pichard, AD and Waksman, R (2015) Clinical outcomes of first- and second-generation drug-eluting stents in patients undergoing rotational atherectomy for heavily calcified coronary lesions. Cardiovasc Revasc Med, 16 (3). pp. 147-150.

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Abstract

BACKGROUND: There is paucity of data regarding the clinical outcome of second generation drug- eluting stents (DES) post rotational atherectomy (RA) for heavily calcified coronary lesions (HCCL). METHODOLOGY: The study cohort comprised 99 (116 lesions) consecutive patients who underwent RA for HCCL at our institution and received either a first generation DES (40 patients, 53 lesions) or a second generation DES (59 patients, 63 lesions). The analyzed clinical parameters were the 12-month rates of death (all cause and cardiac), Q-wave MI, target lesion revascularization (TLR), definite stent thrombosis (ST) and major adverse cardiac events (MACE) defined as the composite of death, Q-wave MI, or TLR. RESULTS: The two groups were well matched for their baseline characteristics except for a lower left ventricular ejection fraction in the second generation DES group (46.0±23.0% vs. 55.0±9.0%; p=0.02). The group receiving second generation DES had more type C lesions (81.0% vs. 58.8%; p=0.01), shorter stent length (19.9±6.1 mm vs. 22.7±7.3 mm; p=0.04) and was more likely to undergo stent postdilatation (52.4% vs. 23.1%; p=0.001). The 1-year analyzed clinical parameters were similar in the two groups: all cause death (8.5% vs. 10.3%; p=1.0), cardiac death (8.5% vs. 2.5%; p=0.40), Q-wave MI (0% vs. 0%), TLR (3.6% vs. 2.7%; p=1.0), ST (0% vs. 0%), and MACE (11.9% vs. 12.8%; p=1.0). The 1-year MACE-free survival rate was also similar in the two cohorts. CONCLUSION: The use of second generation DES, following RA for HCCL, is associated with similar short and long-term clinical outcomes to first generation DES.

Item Type: Article
Authors :
NameEmailORCID
Tian, WUNSPECIFIEDUNSPECIFIED
Mahmoudi, Mm.mahmoudi@surrey.ac.ukUNSPECIFIED
Lhermusier, TUNSPECIFIEDUNSPECIFIED
Pendyala, LKUNSPECIFIEDUNSPECIFIED
Kiramijyan, SUNSPECIFIEDUNSPECIFIED
Saar, MUNSPECIFIEDUNSPECIFIED
Ota, HUNSPECIFIEDUNSPECIFIED
Chen, FUNSPECIFIEDUNSPECIFIED
Torguson, RUNSPECIFIEDUNSPECIFIED
Suddath, WOUNSPECIFIEDUNSPECIFIED
Satler, LFUNSPECIFIEDUNSPECIFIED
Pichard, ADUNSPECIFIEDUNSPECIFIED
Waksman, RUNSPECIFIEDUNSPECIFIED
Date : April 2015
Identification Number : 10.1016/j.carrev.2015.02.004
Uncontrolled Keywords : Calcified coronary lesions, Drug-eluting stents, Rotational atherectomy, Adult, Aged, Aged, 80 and over, Atherectomy, Coronary, Calcinosis, Cardiovascular Agents, Coronary Angiography, Drug-Eluting Stents, Female, Humans, Male, Middle Aged, Myocardial Infarction, Percutaneous Coronary Intervention, Retrospective Studies, Treatment Outcome
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:31
Last Modified : 17 May 2017 10:31
URI: http://epubs.surrey.ac.uk/id/eprint/828145

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