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Efects of selenium supplementation on soluble fms-like tyrosine kinase-1 and glutathione peroxidase levels and the plasminogen activator inhibitor-1: Plasminogen activator inhibitor-2 ratio in pregnant women

Mousavi, M, Heidari, E, Rayman, MP, Tara, F, Boskabadi, H, Mohammadi, S, Maamouri, G, Tavallaie, S, Shakeri, MT, Ghayour-Mobarhan, M and Ferns, G (2015) Efects of selenium supplementation on soluble fms-like tyrosine kinase-1 and glutathione peroxidase levels and the plasminogen activator inhibitor-1: Plasminogen activator inhibitor-2 ratio in pregnant women Shiraz E Medical Journal, 16 (3).

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Abstract

© 2015, Shiraz University of Medical Sciences.Background: Preeclampsia is a hypertensive disorder of pregnancy, which is associated with increased maternal and prenatal morbidity and mortality. Oxidative stress associated with preeclampsia may be a consequence of reduced antioxidant defense pathways that might involve inadequate glutathione peroxidase (GPx) levels, perhaps linked to reduced selenium availability. The soluble FMS-like tyrosine kinase-1 (sFlt-1) that contributes to endothelial dysfunction may be partially responsible for the clinical manifestation of preeclampsia. Furthermore, elevated plasminogen activator inhibitor-1 (PAI-1) and decreased plasminogen activator inhibitor-2 (PAI-2) are found in preeclamptic women. Hence, the PAI1: PAI2 ratio maybe a predictor of preeclampsia. Objectives: The objective of this study was to evaluate the efects of selenium supplementation on sFlt-1, GPx activity and PAI1: PAI2 ratio in pregnant women. Materials and Methods: A total of 125 high-risk pregnant women (with a familial history of hypertension, hyperlipidemia and other risk factors for preeclampsia) in the frst trimesters of pregnancy were assigned to either selenium (n = 61) or placebo (n = 64) groups. The selenium group received 100 μg/day of selenium as a selenium-yeast tablet for six months. The placebo group received a placebo yeast tablet for the same period. At the beginning of the trial and at the end, blood samples were collected and the levels of sFlt-1, PAI-1, PAI2 and GPx were measured in blood serum and plasma. Results: Serum selenium concentrations were raised in the selenium group (P < 0.001) from the frst to the third trimester, but was unchanged in the placebo group (P = 0.85). The results showed that sFlt-1 had signifcantly increased in both groups by the end of the gestation period, and selenium supplementation had no signifcant efect on the selenium group (P = 0.51). However, GPx activity was signifcantly increased in the selenium treatment group after supplementation compared to the control group (P < 0.001). The PAI1: PAI2 ratio was not signifcantly diferent between the two groups (P = 0.44). Conclusions: Selenium intake during the second and third trimester of pregnancy increased GPx activity but did not have a

Item Type: Article
Authors :
NameEmailORCID
Mousavi, MUNSPECIFIEDUNSPECIFIED
Heidari, EUNSPECIFIEDUNSPECIFIED
Rayman, MPm.rayman@surrey.ac.ukUNSPECIFIED
Tara, FUNSPECIFIEDUNSPECIFIED
Boskabadi, HUNSPECIFIEDUNSPECIFIED
Mohammadi, SUNSPECIFIEDUNSPECIFIED
Maamouri, GUNSPECIFIEDUNSPECIFIED
Tavallaie, SUNSPECIFIEDUNSPECIFIED
Shakeri, MTUNSPECIFIEDUNSPECIFIED
Ghayour-Mobarhan, MUNSPECIFIEDUNSPECIFIED
Ferns, GUNSPECIFIEDUNSPECIFIED
Date : 1 January 2015
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:31
Last Modified : 17 May 2017 14:50
URI: http://epubs.surrey.ac.uk/id/eprint/828126

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