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RACK1 mRNA translation is regulated via a rapamycin-sensitive pathway and coordinated with ribosomal protein synthesis

Loreni, F, Iadevaia, V, Tino, E, Caldarola, S and Amaldi, F (2005) RACK1 mRNA translation is regulated via a rapamycin-sensitive pathway and coordinated with ribosomal protein synthesis FEBS Letters, 579, 25. 5517 - 5520 - 5517 - 5520.

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Abstract

RACK1 has been shown to interact with several proteins, this suggesting that it may play a central role in cell growth regulation. Some recent articles have described RACK1 as a component of the small ribosomal subunit. To investigate the relationship between RACK1 and ribosome, we analyzed RACK1 mRNA structure and regulation. Translational regulation was studied in HeLa cells subjected to serum or amino acid deprivation and stimulation. The results show that RACK1 mRNA has a 5′ terminal oligopyrimidine sequence and that its translation is dependent on the availability of serum and amino acids in exactly the same way as any other vertebrate ribosomal protein mRNA.

Item Type: Article
Authors :
NameEmailORCID
Loreni, FUNSPECIFIEDUNSPECIFIED
Iadevaia, Vv.iadevaia@surrey.ac.ukUNSPECIFIED
Tino, EUNSPECIFIEDUNSPECIFIED
Caldarola, SUNSPECIFIEDUNSPECIFIED
Amaldi, FUNSPECIFIEDUNSPECIFIED
Date : 2005
Identification Number : https://doi.org/10.1016/j.febslet.2005.09.016
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:29
Last Modified : 17 May 2017 14:49
URI: http://epubs.surrey.ac.uk/id/eprint/827999

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