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Protected by nature? Effects of strenuous physical exercise on FVIII activity in moderate and mild haemophilia A patients: a pilot study.

Groen, WG, den Uijl, IE, van der Net, J, Grobbee, DE, de Groot, PG and Fischer, K (2013) Protected by nature? Effects of strenuous physical exercise on FVIII activity in moderate and mild haemophilia A patients: a pilot study. Haemophilia, 19 (4). pp. 519-523.

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Abstract

Increase of factor VIII activity (FVIII) after physical exercise has been reported in healthy subjects and small-scale studies in patients with coagulopathies. The aim was to study whether moderate and mild haemophilia A patients are able to increase their endogenous FVIII activity levels by physical activity. We studied changes in FVIII activity levels after high-intensity exercise in 15 haemophilia A patients, 20-39 years, eight with moderate, seven with mild haemophilia. Patients cycled until volitional exhaustion, blood samples were drawn before and 10 min after the exercise test. FVIII activity increased 2.5 times (range 1.8-7.0 times), for both severities. Absolute increases were markedly different: median 7 IU dL(-1) (range 3-9 IU dL(-1) ) in patients with moderate, compared to 15 IU dL(-1) (range 6-62 IU dL(-1) ) in mild haemophilia patients. VWF and VWFpp increased independently of severity; median 50% (range 8-123%) and median 165% (range 48-350%), respectively, reflecting acute release of VWF. These observations may be used to promote high-intensity activities before participating in sports for moderate and mild haemophilia A patients, to reduce bleeding risk. Further studies are warranted to fully appreciate the clinical significance of exercise on different levels of intensity in patients with mild and moderate haemophilia A.

Item Type: Article
Authors :
NameEmailORCID
Groen, WGUNSPECIFIEDUNSPECIFIED
den Uijl, IEi.denuijl@surrey.ac.ukUNSPECIFIED
van der Net, JUNSPECIFIEDUNSPECIFIED
Grobbee, DEUNSPECIFIEDUNSPECIFIED
de Groot, PGUNSPECIFIEDUNSPECIFIED
Fischer, KUNSPECIFIEDUNSPECIFIED
Date : July 2013
Identification Number : https://doi.org/10.1111/hae.12111
Uncontrolled Keywords : Adult, Blood Coagulation, Deamino Arginine Vasopressin, Exercise, Factor VIII, Hemophilia A, Humans, Nature, Pilot Projects, Young Adult
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:29
Last Modified : 17 May 2017 14:49
URI: http://epubs.surrey.ac.uk/id/eprint/827984

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