University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Calf-level factors associated with bovine neonatal pancytopenia--a multi-country case-control study.

Jones, BA, Sauter-Louis, C, Henning, J, Stoll, A, Nielen, M, Van Schaik, G, Smolenaars, A, Schouten, M, den Uijl, I, Fourichon, C, Guatteo, R, Madouasse, A, Nusinovici, S, Deprez, P, De Vliegher, S, Laureyns, J, Booth, R, Cardwell, JM and Pfeiffer, DU (2013) Calf-level factors associated with bovine neonatal pancytopenia--a multi-country case-control study. PLoS One, 8 (12).

Full text not available from this repository.

Abstract

Bovine neonatal pancytopenia (BNP), a high fatality condition causing haemorrhages in calves aged less than 4 weeks, was first reported in 2007 in Germany and subsequently observed at low incidence in other European countries and New Zealand. A multi-country matched case-control study was conducted in 2011 to identify calf-level risk factors for BNP. 405 BNP cases were recruited from 330 farms in Belgium, France, Germany and the Netherlands by laboratory confirmation of farmer-reported cases. Up to four calves of similar age from the same farm were selected as controls (1154 calves). Risk factor data were collected by questionnaire. Multivariable modelling using conditional logistic regression indicated that PregSure®BVD (PregSure, Pfizer Animal Health) vaccination of the dam was strongly associated with BNP cases (adjusted matched Odds Ratio - amOR 17.8 first lactation dams; 95% confidence interval - ci 2.4, 134.4; p = 0.005), and second or more lactation PregSure-vaccinated dams were more likely to have a case than first lactation vaccinated dams (amOR 2.2 second lactation; ci 1.1, 4.3; p = 0.024; amOR 5.3 third or more lactation; ci 2.9, 9.8; p = <0.001). Feeding colostrum from other cows was strongly associated with BNP if the dam was not PregSure-vaccinated (amOR 30.5; ci 2.1, 440.5; p = 0.012), but the effect was less if the dam was PregSure-vaccinated (amOR 2.1; ci 1.1, 4.0; p = 0.024). Feeding exclusively dam's milk was a higher risk than other types of milk (amOR 3.4; ci 1.6, 7.5; p = 0.002). The population attributable fractions were 0.84 (ci 0.68, 0.92) for PregSure vaccination, 0.13 (ci 0.06, 0.19) for feeding other cows' colostrum, and 0.15 (ci 0.08, 0.22) for feeding dam's milk. No other calf-level factors were identified, suggesting that there are other important factors that are outside the scope of this study, such as genetics, which explain why BNP develops in some PregSure-colostrum-exposed calves but not in others.

Item Type: Article
Authors :
NameEmailORCID
Jones, BAUNSPECIFIEDUNSPECIFIED
Sauter-Louis, CUNSPECIFIEDUNSPECIFIED
Henning, JUNSPECIFIEDUNSPECIFIED
Stoll, AUNSPECIFIEDUNSPECIFIED
Nielen, MUNSPECIFIEDUNSPECIFIED
Van Schaik, GUNSPECIFIEDUNSPECIFIED
Smolenaars, AUNSPECIFIEDUNSPECIFIED
Schouten, MUNSPECIFIEDUNSPECIFIED
den Uijl, Ii.denuijl@surrey.ac.ukUNSPECIFIED
Fourichon, CUNSPECIFIEDUNSPECIFIED
Guatteo, RUNSPECIFIEDUNSPECIFIED
Madouasse, AUNSPECIFIEDUNSPECIFIED
Nusinovici, SUNSPECIFIEDUNSPECIFIED
Deprez, PUNSPECIFIEDUNSPECIFIED
De Vliegher, SUNSPECIFIEDUNSPECIFIED
Laureyns, JUNSPECIFIEDUNSPECIFIED
Booth, RUNSPECIFIEDUNSPECIFIED
Cardwell, JMUNSPECIFIEDUNSPECIFIED
Pfeiffer, DUUNSPECIFIEDUNSPECIFIED
Date : 2013
Identification Number : https://doi.org/10.1371/journal.pone.0080619
Uncontrolled Keywords : Animals, Bovine Virus Diarrhea-Mucosal Disease, Cattle, Diarrhea Virus 1, Bovine Viral, Europe, Hemorrhage, Models, Biological, Pancytopenia, Vaccination, Viral Vaccines
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:28
Last Modified : 17 May 2017 14:49
URI: http://epubs.surrey.ac.uk/id/eprint/827925

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800