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Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes.

Graham, SP, Pellé, R, Honda, Y, Mwangi, DM, Tonukari, NJ, Yamage, M, Glew, EJ, de Villiers, EP, Shah, T, Bishop, R , Abuya, E, Awino, E, Gachanja, J, Luyai, AE, Mbwika, F, Muthiani, AM, Ndegwa, DM, Njahira, M, Nyanjui, JK, Onono, FO, Osaso, J, Saya, RM, Wildmann, C, Fraser, CM, Maudlin, I, Gardner, MJ, Morzaria, SP, Loosmore, S, Gilbert, SC, Audonnet, JC, van der Bruggen, P, Nene, V and Taracha, EL (2006) Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes. Proc Natl Acad Sci U S A, 103 (9). pp. 3286-3291.

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Abstract

East Coast fever, caused by the tick-borne intracellular apicomplexan parasite Theileria parva, is a highly fatal lymphoproliferative disease of cattle. The pathogenic schizont-induced lymphocyte transformation is a unique cancer-like condition that is reversible with parasite removal. Schizont-infected cell-directed CD8(+) cytotoxic T lymphocytes (CTL) constitute the dominant protective bovine immune response after a single exposure to infection. However, the schizont antigens targeted by T. parva-specific CTL are undefined. Here we show the identification of five candidate vaccine antigens that are the targets of MHC class I-restricted CD8(+) CTL from immune cattle. CD8(+) T cell responses to these antigens were boosted in T. parva-immune cattle resolving a challenge infection and, when used to immunize naïve cattle, induced CTL responses that significantly correlated with survival from a lethal parasite challenge. These data provide a basis for developing a CTL-targeted anti-East Coast fever subunit vaccine. In addition, orthologs of these antigens may be vaccine targets for other apicomplexan parasites.

Item Type: Article
Authors :
NameEmailORCID
Graham, SPs.graham@surrey.ac.ukUNSPECIFIED
Pellé, RUNSPECIFIEDUNSPECIFIED
Honda, YUNSPECIFIEDUNSPECIFIED
Mwangi, DMUNSPECIFIEDUNSPECIFIED
Tonukari, NJUNSPECIFIEDUNSPECIFIED
Yamage, MUNSPECIFIEDUNSPECIFIED
Glew, EJUNSPECIFIEDUNSPECIFIED
de Villiers, EPUNSPECIFIEDUNSPECIFIED
Shah, TUNSPECIFIEDUNSPECIFIED
Bishop, RUNSPECIFIEDUNSPECIFIED
Abuya, EUNSPECIFIEDUNSPECIFIED
Awino, EUNSPECIFIEDUNSPECIFIED
Gachanja, JUNSPECIFIEDUNSPECIFIED
Luyai, AEUNSPECIFIEDUNSPECIFIED
Mbwika, FUNSPECIFIEDUNSPECIFIED
Muthiani, AMUNSPECIFIEDUNSPECIFIED
Ndegwa, DMUNSPECIFIEDUNSPECIFIED
Njahira, MUNSPECIFIEDUNSPECIFIED
Nyanjui, JKUNSPECIFIEDUNSPECIFIED
Onono, FOUNSPECIFIEDUNSPECIFIED
Osaso, JUNSPECIFIEDUNSPECIFIED
Saya, RMUNSPECIFIEDUNSPECIFIED
Wildmann, CUNSPECIFIEDUNSPECIFIED
Fraser, CMUNSPECIFIEDUNSPECIFIED
Maudlin, IUNSPECIFIEDUNSPECIFIED
Gardner, MJUNSPECIFIEDUNSPECIFIED
Morzaria, SPUNSPECIFIEDUNSPECIFIED
Loosmore, SUNSPECIFIEDUNSPECIFIED
Gilbert, SCUNSPECIFIEDUNSPECIFIED
Audonnet, JCUNSPECIFIEDUNSPECIFIED
van der Bruggen, PUNSPECIFIEDUNSPECIFIED
Nene, VUNSPECIFIEDUNSPECIFIED
Taracha, ELUNSPECIFIEDUNSPECIFIED
Date : 28 February 2006
Identification Number : 10.1073/pnas.0511273103
Uncontrolled Keywords : Animals, Antigens, Protozoan, Cattle, Cell Line, Protozoan Vaccines, T-Lymphocytes, Cytotoxic, Theileria parva, Theileriasis, Vaccination
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:22
Last Modified : 17 May 2017 14:49
URI: http://epubs.surrey.ac.uk/id/eprint/827513

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