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Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes.

Graham, SP, Pellé, R, Honda, Y, Mwangi, DM, Tonukari, NJ, Yamage, M, Glew, EJ, de Villiers, EP, Shah, T, Bishop, R , Abuya, E, Awino, E, Gachanja, J, Luyai, AE, Mbwika, F, Muthiani, AM, Ndegwa, DM, Njahira, M, Nyanjui, JK, Onono, FO, Osaso, J, Saya, RM, Wildmann, C, Fraser, CM, Maudlin, I, Gardner, MJ, Morzaria, SP, Loosmore, S, Gilbert, SC, Audonnet, JC, van der Bruggen, P, Nene, V and Taracha, EL (2006) Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes. Proc Natl Acad Sci U S A, 103 (9). pp. 3286-3291.

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East Coast fever, caused by the tick-borne intracellular apicomplexan parasite Theileria parva, is a highly fatal lymphoproliferative disease of cattle. The pathogenic schizont-induced lymphocyte transformation is a unique cancer-like condition that is reversible with parasite removal. Schizont-infected cell-directed CD8(+) cytotoxic T lymphocytes (CTL) constitute the dominant protective bovine immune response after a single exposure to infection. However, the schizont antigens targeted by T. parva-specific CTL are undefined. Here we show the identification of five candidate vaccine antigens that are the targets of MHC class I-restricted CD8(+) CTL from immune cattle. CD8(+) T cell responses to these antigens were boosted in T. parva-immune cattle resolving a challenge infection and, when used to immunize naïve cattle, induced CTL responses that significantly correlated with survival from a lethal parasite challenge. These data provide a basis for developing a CTL-targeted anti-East Coast fever subunit vaccine. In addition, orthologs of these antigens may be vaccine targets for other apicomplexan parasites.

Item Type: Article
Divisions : Surrey research (other units)
Authors :
Pellé, R
Honda, Y
Mwangi, DM
Tonukari, NJ
Yamage, M
Glew, EJ
de Villiers, EP
Shah, T
Bishop, R
Abuya, E
Awino, E
Gachanja, J
Luyai, AE
Mbwika, F
Muthiani, AM
Ndegwa, DM
Njahira, M
Nyanjui, JK
Onono, FO
Osaso, J
Saya, RM
Wildmann, C
Fraser, CM
Maudlin, I
Gardner, MJ
Morzaria, SP
Loosmore, S
Gilbert, SC
Audonnet, JC
van der Bruggen, P
Nene, V
Taracha, EL
Date : 28 February 2006
DOI : 10.1073/pnas.0511273103
Uncontrolled Keywords : Animals, Antigens, Protozoan, Cattle, Cell Line, Protozoan Vaccines, T-Lymphocytes, Cytotoxic, Theileria parva, Theileriasis, Vaccination
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:22
Last Modified : 24 Jan 2020 19:07

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