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Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4+ cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva.

Graham, SP, Saya, R, Awino, E, Ngugi, D, Nyanjui, JK, Hecker, R, Taracha, EL and Nene, V (2007) Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4+ cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva. Vet Immunol Immunopathol, 115 (3-4). pp. 383-389.

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Abstract

Enhancement of the induction of cytotoxic T-cell responses by immunostimulatory CpG oligodeoxynucleotides has been described in humans and mouse models. The present study attempted to address whether CpG has a similar effect in cattle. Immunisation of cattle with a recombinant form of the polymorphic immunodominant molecule from Theileria parva emulsified with immunostimulatory CpG oligodeoxynucleotides in adjuvant had no effect on the induction of antibody responses including the isotype profile, but significantly enhanced the induction of cytolytic responses that were mediated by CD4+CD3+ T cells utilizing the perforin-granzyme pathway.

Item Type: Article
Authors :
NameEmailORCID
Graham, SPs.graham@surrey.ac.ukUNSPECIFIED
Saya, RUNSPECIFIEDUNSPECIFIED
Awino, EUNSPECIFIEDUNSPECIFIED
Ngugi, DUNSPECIFIEDUNSPECIFIED
Nyanjui, JKUNSPECIFIEDUNSPECIFIED
Hecker, RUNSPECIFIEDUNSPECIFIED
Taracha, ELUNSPECIFIEDUNSPECIFIED
Nene, VUNSPECIFIEDUNSPECIFIED
Date : 15 February 2007
Identification Number : https://doi.org/10.1016/j.vetimm.2006.11.010
Uncontrolled Keywords : Adjuvants, Immunologic, Amino Acid Sequence, Animals, Antibodies, Protozoan, Antigens, Protozoan, CD4-Positive T-Lymphocytes, Cattle, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunization, Interferon-gamma, Lymphocyte Activation, Male, Molecular Sequence Data, Oligodeoxyribonucleotides, Protozoan Proteins, Recombinant Fusion Proteins, T-Lymphocytes, Cytotoxic, Theileria parva, Theileriasis
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:22
Last Modified : 17 May 2017 14:49
URI: http://epubs.surrey.ac.uk/id/eprint/827511

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