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Effects of increasing insulin secretion on acute postexercise blood glucose disposal.

Kaastra, B, Manders, RJ, Van Breda, E, Kies, A, Jeukendrup, AE, Keizer, HA, Kuipers, H and Van Loon, LJ (2006) Effects of increasing insulin secretion on acute postexercise blood glucose disposal. Med Sci Sports Exerc, 38 (2). pp. 268-275.

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Abstract

BACKGROUND: Coingestion of protein and/or free amino acids with carbohydrate has been reported to accelerate postexercise muscle glycogen synthesis due to an increase in the insulin response. PURPOSE: To determine the extent to which the combined ingestion of carbohydrate and a casein protein hydrolysate with or without additional free leucine can increase insulin levels during postexercise recovery in endurance-trained athletes. To determine how this affects whole-body plasma glucose disposal during postexercise recovery. METHODS: Fourteen male athletes (age: 24.3 +/- 0.8 yr; VO2max: 62.9 +/- 1.4 mL.kg.min) were subjected to three randomized crossover trials in which they performed 2 h of exercise (55% Wmax). Thereafter, subjects were studied for 3.5 h during which they ingested carbohydrate (CHO: 0.8 g.kg.h), carbohydrate and a protein hydrolysate (CHO-PRO: 0.8 and 0.4 g.kg.h, respectively), or carbohydrate, a protein hydrolysate, and free leucine (CHO-PRO-LEU: 0.8, 0.4, and 0.1 g.kg.h, respectively) in a double-blind fashion. Continuous infusions with [6,6-H2] glucose were applied to quantify plasma glucose appearance (Ra) and disappearance rates (Rd). RESULTS: Plasma insulin responses were 108 +/- 17 and 190 +/- 33% greater in the CHO-PRO and CHO-PRO-LEU trial, respectively, compared with the CHO-trial (P < 0.01). Plasma glucose responses were lower in the CHO-PRO and CHO-PRO-LEU trial compared with the CHO-trial (35 +/- 5 and 42 +/- 11% lower, respectively; P < 0.01). Plasma glucose Ra and Rd were greater in the CHO versus the CHO-PRO and CHO-PRO-LEU trials (P < 0.05). Glucose Rd represented 100 +/- 0.03% of Ra in all trials. CONCLUSIONS: The combined ingestion of a protein hydrolysate and/or free leucine with carbohydrate (0.8 g.kg.h) substantially augments insulin secretion, but does not affect plasma glucose disposal during the first 3.5 h of postexercise recovery in trained athletes.

Item Type: Article
Authors :
NameEmailORCID
Kaastra, BUNSPECIFIEDUNSPECIFIED
Manders, RJr.manders@surrey.ac.ukUNSPECIFIED
Van Breda, EUNSPECIFIEDUNSPECIFIED
Kies, AUNSPECIFIEDUNSPECIFIED
Jeukendrup, AEUNSPECIFIEDUNSPECIFIED
Keizer, HAUNSPECIFIEDUNSPECIFIED
Kuipers, HUNSPECIFIEDUNSPECIFIED
Van Loon, LJUNSPECIFIEDUNSPECIFIED
Date : February 2006
Identification Number : 10.1249/01.mss.0000183875.86476.bd
Uncontrolled Keywords : Adult, Analysis of Variance, Bicycling, Blood Glucose, Cross-Over Studies, Dietary Carbohydrates, Exercise Test, Humans, Insulin, Leucine, Male, Muscle, Skeletal, Protein Hydrolysates, Surveys and Questionnaires
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:22
Last Modified : 17 May 2017 14:49
URI: http://epubs.surrey.ac.uk/id/eprint/827503

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