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The muscle protein synthetic response to carbohydrate and protein ingestion is not impaired in men with longstanding type 2 diabetes.

Manders, RJ, Koopman, R, Beelen, M, Gijsen, AP, Wodzig, WK, Saris, WH and van Loon, LJ (2008) The muscle protein synthetic response to carbohydrate and protein ingestion is not impaired in men with longstanding type 2 diabetes. J Nutr, 138 (6). pp. 1079-1085.

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Abstract

Protein ingestion stimulates muscle protein synthesis and improves net muscle protein balance. Insulin resistance has been suggested to result in a reduced muscle protein synthetic response to food intake. As such, we hypothesized that type 2 diabetes patients have a impaired muscle protein synthetic response to food ingestion. To test this hypothesis, 10 male type 2 diabetes patients using their normal oral glucose-lowering medication (68 +/- 2 y) and 10 matched, normoglycemic men (65 +/- 2 y) were randomly assigned to 2 crossover treatments in which whole body and muscle protein synthesis were measured following the consumption of either carbohydrate (CHO) or carbohydrate with a protein hydrolysate (CHO+PRO). Primed, continuous infusions with L-[ring-13C6]phenylalanine and L-[ring-2H2]tyrosine were applied and blood and muscle samples were collected to assess whole-body protein balance and mixed muscle protein fractional synthetic rate over a 6-h period. Whole-body phenylalanine and tyrosine flux were higher after the CHO+PRO treatment compared with the CHO treatment in the diabetes and control group (P < 0.01). Protein balance was negative following CHO but positive following CHO+PRO treatment in both groups. Muscle protein synthesis rates were higher in both groups following the CHO+PRO (0.086 +/- 0.014%/h) treatment than in the CHO treatment (0.040 +/- 0.003%/h; P < 0.01) with no difference between the diabetes patients and normoglycemic controls. We conclude that the muscle protein synthetic response to CHO or CHO+PRO ingestion is not substantially impaired in longstanding, type 2 diabetes patients treated with oral blood glucose-lowering medication.

Item Type: Article
Authors :
NameEmailORCID
Manders, RJr.manders@surrey.ac.ukUNSPECIFIED
Koopman, RUNSPECIFIEDUNSPECIFIED
Beelen, MUNSPECIFIEDUNSPECIFIED
Gijsen, APUNSPECIFIEDUNSPECIFIED
Wodzig, WKUNSPECIFIEDUNSPECIFIED
Saris, WHUNSPECIFIEDUNSPECIFIED
van Loon, LJUNSPECIFIEDUNSPECIFIED
Date : June 2008
Uncontrolled Keywords : Aged, Amino Acids, Blood Glucose, Cross-Over Studies, Diabetes Mellitus, Type 2, Diet, Dietary Carbohydrates, Dietary Proteins, Dietary Supplements, Energy Metabolism, Gene Expression Regulation, Humans, Insulin, Male, Muscle Proteins, Muscle, Skeletal
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:22
Last Modified : 17 May 2017 14:49
URI: http://epubs.surrey.ac.uk/id/eprint/827496

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