Prevalence of daily hyperglycemia in obese type 2 diabetic men compared with that in lean and obese normoglycemic men: effect of consumption of a sucrose-containing beverage.

Manders, RJ, Pennings, B, Beckers, CP, Aipassa, TI and van Loon, LJ (2009) Prevalence of daily hyperglycemia in obese type 2 diabetic men compared with that in lean and obese normoglycemic men: effect of consumption of a sucrose-containing beverage. Am J Clin Nutr, 90 (3). pp. 511-518.

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Abstract

BACKGROUND: Hyperglycemia forms a direct and independent risk factor for the development of cardiovascular comorbidities in type 2 diabetes. Consumption of sucrose-sweetened soft drinks might further increase the prevalence of hyperglycemic episodes. OBJECTIVE: The objective was to assess glycemic control in type 2 diabetic subjects and healthy lean and obese control subjects under strict dietary standardization but otherwise free-living conditions, with and without the consumption of soft drinks. DESIGN: Obese type 2 diabetic men (n = 11) and lean (n = 10) and obese (n = 10) normoglycemic male control subjects participated in a randomized crossover study. The subjects were provided with a standardized diet in 2 periods, during which they consumed 250 mL water with or without (control) sucrose (37.5 g) 2 h after breakfast and lunch. Blood glucose concentrations were assessed by continuous glucose monitoring. RESULTS: In the type 2 diabetic subjects, the mean 24-h glucose concentrations were significantly elevated (9.1 +/- 0.6 mmol/L), and hyperglycemia (glucose >10 mmol/L) was evident over 33 +/- 8% (8 +/- 2 h) of a 24-h period (P < 0.01). Hyperglycemia was rarely present in the normoglycemic lean and obese control subjects (5 +/- 2%/24 h for both). Consumption of 75 g sucrose, equivalent to 2 cans of a soft drink, did not further augment the prevalence of hyperglycemia throughout the day in any group. CONCLUSIONS: Type 2 diabetic subjects taking oral blood glucose-lowering medication experience hyperglycemia during most of the daytime. Moderate consumption of sucrose-sweetened beverages does not further increase the prevalence of hyperglycemia in type 2 diabetic subjects or in normoglycemic lean or obese men.

Item Type:	Article
Authors :	Name Email ORCID Manders, RJ r.manders@surrey.ac.uk Pennings, B Beckers, CP Aipassa, TI van Loon, LJ
Date :	September 2009
Identification Number :	10.3945/ajcn.2008.27072
Uncontrolled Keywords :	Beverages, Blood Glucose, Cross-Over Studies, Diabetes Mellitus, Type 2, Dietary Carbohydrates, Double-Blind Method, Humans, Hyperglycemia, Male, Obesity, Prevalence, Sucrose
Related URLs :	Author
Depositing User :	Symplectic Elements
Date Deposited :	17 May 2017 10:22
Last Modified :	17 May 2017 14:49
URI:	http://epubs.surrey.ac.uk/id/eprint/827495

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