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Postprandial hyperglycemia is highly prevalent throughout the day in type 2 diabetes patients.

van Dijk, JW, Manders, RJ, Hartgens, F, Stehouwer, CD, Praet, SF and van Loon, LJ (2011) Postprandial hyperglycemia is highly prevalent throughout the day in type 2 diabetes patients. Diabetes Res Clin Pract, 93 (1). pp. 31-37.

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Abstract

AIM: Although postprandial hyperglycemia is recognized as an important target in type 2 diabetes treatment, information on the prevalence of postprandial hyperglycemia throughout the day is limited. Therefore, we assessed the prevalence of hyperglycemia throughout the day in type 2 diabetes patients and healthy controls under standardized dietary, but otherwise free-living conditions. METHODS: 60 male type 2 diabetes patients (HbA(1c) 7.5±0.1% [58±1 mmol/mol]) and 24 age- and BMI-matched normal glucose tolerant controls were recruited to participate in a comparative study of daily glycemic control. During a 3-day experimental period, blood glucose concentrations throughout the day were assessed by continuous glucose monitoring. RESULTS: Type 2 diabetes patients experienced hyperglycemia (glucose concentrations >10 mmol/L) 38±4% of the day. Even diabetes patients with an HbA(1c) level below 7.0% (53 mmol/mol) experienced hyperglycemia for as much as 24±5% throughout the day. Hyperglycemia was negligible in the control group (3±1%). CONCLUSION: Hyperglycemia is highly prevalent throughout the day in type 2 diabetes patients, even in those patients with a HbA(1c) level well below 7.0% (53 mmol/mol). Standard medical care with prescription of oral blood glucose lowering medication does not provide ample protection against postprandial hyperglycemia.

Item Type: Article
Authors :
NameEmailORCID
van Dijk, JWUNSPECIFIEDUNSPECIFIED
Manders, RJr.manders@surrey.ac.ukUNSPECIFIED
Hartgens, FUNSPECIFIEDUNSPECIFIED
Stehouwer, CDUNSPECIFIEDUNSPECIFIED
Praet, SFUNSPECIFIEDUNSPECIFIED
van Loon, LJUNSPECIFIEDUNSPECIFIED
Date : July 2011
Identification Number : 10.1016/j.diabres.2011.03.021
Uncontrolled Keywords : Blood Glucose, Diabetes Mellitus, Type 2, Hemoglobin A, Glycosylated, Humans, Hyperglycemia, Male, Middle Aged
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:22
Last Modified : 17 May 2017 14:49
URI: http://epubs.surrey.ac.uk/id/eprint/827493

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