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Investigating air pollution and atherosclerosis in humans: concepts and outlook.

Künzli, N, Perez, L, von Klot, S, Baldassarre, D, Bauer, M, Basagana, X, Breton, C, Dratva, J, Elosua, R, de Faire, U , Fuks, K, de Groot, E, Marrugat, J, Penell, J, Seissler, J, Peters, A and Hoffmann, B (2011) Investigating air pollution and atherosclerosis in humans: concepts and outlook. Prog Cardiovasc Dis, 53 (5). pp. 334-343.

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Although ambient particulate matter contributes to atherosclerosis in animal models, its role in atherogenesis in humans needs to be established. This article discusses concepts, study design, and choice of health outcomes to efficiently investigate the atherogenic role of ambient air pollution, with an emphasis on early preclinical biomarkers of atherosclerosis that are unaffected by short-term exposure to air pollution (eg, carotid intima-media thickness [CIMT] and functional performance of the vessel). Air pollution studies using these end points are summarized. The CIMT is currently the most frequently used outcome in this field (6 studies). The continuous nature of CIMT, the lack of short-term variation, its relationship to atherosclerotic changes in the artery wall, its predictive value for coronary heart disease, and the noninvasiveness of the assessment make it a useful candidate for cross-sectional and longitudinal studies investigating the role of air pollution in atherogenesis.

Item Type: Article
Divisions : Surrey research (other units)
Authors :
Künzli, N
Perez, L
von Klot, S
Baldassarre, D
Bauer, M
Basagana, X
Breton, C
Dratva, J
Elosua, R
de Faire, U
Fuks, K
de Groot, E
Marrugat, J
Seissler, J
Peters, A
Hoffmann, B
Date : March 2011
DOI : 10.1016/j.pcad.2010.12.006
Uncontrolled Keywords : Atherosclerosis, Biomarkers, Biomedical Research, Endpoint Determination, Evidence-Based Medicine, Humans, Inhalation Exposure, Particulate Matter, Public Health, Research Design, Risk Assessment, Risk Factors
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:19
Last Modified : 24 Jan 2020 18:58

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