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Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE).

Raaschou-Nielsen, O, Andersen, ZJ, Beelen, R, Samoli, E, Stafoggia, M, Weinmayr, G, Hoffmann, B, Fischer, P, Nieuwenhuijsen, MJ, Brunekreef, B, Xun, WW, Katsouyanni, K, Dimakopoulou, K, Sommar, J, Forsberg, B, Modig, L, Oudin, A, Oftedal, B, Schwarze, PE, Nafstad, P, De Faire, U, Pedersen, NL, Ostenson, CG, Fratiglioni, L, Penell, J, Korek, M, Pershagen, G, Eriksen, KT, Sørensen, M, Tjønneland, A, Ellermann, T, Eeftens, M, Peeters, PH, Meliefste, K, Wang, M, Bueno-de-Mesquita, B, Key, TJ, de Hoogh, K, Concin, H, Nagel, G, Vilier, A, Grioni, S, Krogh, V, Tsai, MY, Ricceri, F, Sacerdote, C, Galassi, C, Migliore, E, Ranzi, A, Cesaroni, G, Badaloni, C, Forastiere, F, Tamayo, I, Amiano, P, Dorronsoro, M, Trichopoulou, A, Bamia, C, Vineis, P and Hoek, G (2013) Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE). Lancet Oncol, 14 (9). pp. 813-822.

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Abstract

BACKGROUND: Ambient air pollution is suspected to cause lung cancer. We aimed to assess the association between long-term exposure to ambient air pollution and lung cancer incidence in European populations. METHODS: This prospective analysis of data obtained by the European Study of Cohorts for Air Pollution Effects used data from 17 cohort studies based in nine European countries. Baseline addresses were geocoded and we assessed air pollution by land-use regression models for particulate matter (PM) with diameter of less than 10 μm (PM10), less than 2·5 μm (PM2·5), and between 2·5 and 10 μm (PMcoarse), soot (PM2·5absorbance), nitrogen oxides, and two traffic indicators. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effects models for meta-analyses. FINDINGS: The 312 944 cohort members contributed 4 013 131 person-years at risk. During follow-up (mean 12·8 years), 2095 incident lung cancer cases were diagnosed. The meta-analyses showed a statistically significant association between risk for lung cancer and PM10 (hazard ratio [HR] 1·22 [95% CI 1·03-1·45] per 10 μg/m(3)). For PM2·5 the HR was 1·18 (0·96-1·46) per 5 μg/m(3). The same increments of PM10 and PM2·5 were associated with HRs for adenocarcinomas of the lung of 1·51 (1·10-2·08) and 1·55 (1·05-2·29), respectively. An increase in road traffic of 4000 vehicle-km per day within 100 m of the residence was associated with an HR for lung cancer of 1·09 (0·99-1·21). The results showed no association between lung cancer and nitrogen oxides concentration (HR 1·01 [0·95-1·07] per 20 μg/m(3)) or traffic intensity on the nearest street (HR 1·00 [0·97-1·04] per 5000 vehicles per day). INTERPRETATION: Particulate matter air pollution contributes to lung cancer incidence in Europe. FUNDING: European Community's Seventh Framework Programme.

Item Type: Article
Authors :
NameEmailORCID
Raaschou-Nielsen, OUNSPECIFIEDUNSPECIFIED
Andersen, ZJUNSPECIFIEDUNSPECIFIED
Beelen, RUNSPECIFIEDUNSPECIFIED
Samoli, EUNSPECIFIEDUNSPECIFIED
Stafoggia, MUNSPECIFIEDUNSPECIFIED
Weinmayr, GUNSPECIFIEDUNSPECIFIED
Hoffmann, BUNSPECIFIEDUNSPECIFIED
Fischer, PUNSPECIFIEDUNSPECIFIED
Nieuwenhuijsen, MJUNSPECIFIEDUNSPECIFIED
Brunekreef, BUNSPECIFIEDUNSPECIFIED
Xun, WWUNSPECIFIEDUNSPECIFIED
Katsouyanni, KUNSPECIFIEDUNSPECIFIED
Dimakopoulou, KUNSPECIFIEDUNSPECIFIED
Sommar, JUNSPECIFIEDUNSPECIFIED
Forsberg, BUNSPECIFIEDUNSPECIFIED
Modig, LUNSPECIFIEDUNSPECIFIED
Oudin, AUNSPECIFIEDUNSPECIFIED
Oftedal, BUNSPECIFIEDUNSPECIFIED
Schwarze, PEUNSPECIFIEDUNSPECIFIED
Nafstad, PUNSPECIFIEDUNSPECIFIED
De Faire, UUNSPECIFIEDUNSPECIFIED
Pedersen, NLUNSPECIFIEDUNSPECIFIED
Ostenson, CGUNSPECIFIEDUNSPECIFIED
Fratiglioni, LUNSPECIFIEDUNSPECIFIED
Penell, Jj.penell@surrey.ac.ukUNSPECIFIED
Korek, MUNSPECIFIEDUNSPECIFIED
Pershagen, GUNSPECIFIEDUNSPECIFIED
Eriksen, KTUNSPECIFIEDUNSPECIFIED
Sørensen, MUNSPECIFIEDUNSPECIFIED
Tjønneland, AUNSPECIFIEDUNSPECIFIED
Ellermann, TUNSPECIFIEDUNSPECIFIED
Eeftens, MUNSPECIFIEDUNSPECIFIED
Peeters, PHUNSPECIFIEDUNSPECIFIED
Meliefste, KUNSPECIFIEDUNSPECIFIED
Wang, MUNSPECIFIEDUNSPECIFIED
Bueno-de-Mesquita, BUNSPECIFIEDUNSPECIFIED
Key, TJUNSPECIFIEDUNSPECIFIED
de Hoogh, KUNSPECIFIEDUNSPECIFIED
Concin, HUNSPECIFIEDUNSPECIFIED
Nagel, GUNSPECIFIEDUNSPECIFIED
Vilier, AUNSPECIFIEDUNSPECIFIED
Grioni, SUNSPECIFIEDUNSPECIFIED
Krogh, VUNSPECIFIEDUNSPECIFIED
Tsai, MYUNSPECIFIEDUNSPECIFIED
Ricceri, FUNSPECIFIEDUNSPECIFIED
Sacerdote, CUNSPECIFIEDUNSPECIFIED
Galassi, CUNSPECIFIEDUNSPECIFIED
Migliore, EUNSPECIFIEDUNSPECIFIED
Ranzi, AUNSPECIFIEDUNSPECIFIED
Cesaroni, GUNSPECIFIEDUNSPECIFIED
Badaloni, CUNSPECIFIEDUNSPECIFIED
Forastiere, FUNSPECIFIEDUNSPECIFIED
Tamayo, IUNSPECIFIEDUNSPECIFIED
Amiano, PUNSPECIFIEDUNSPECIFIED
Dorronsoro, MUNSPECIFIEDUNSPECIFIED
Trichopoulou, AUNSPECIFIEDUNSPECIFIED
Bamia, CUNSPECIFIEDUNSPECIFIED
Vineis, PUNSPECIFIEDUNSPECIFIED
Hoek, GUNSPECIFIEDUNSPECIFIED
Date : August 2013
Identification Number : https://doi.org/10.1016/S1470-2045(13)70279-1
Uncontrolled Keywords : Adenocarcinoma, Adult, Aged, Air Pollution, Carcinoma, Squamous Cell, Environmental Exposure, Europe, Female, Follow-Up Studies, Humans, Incidence, Lung Neoplasms, Male, Middle Aged, Particulate Matter, Prognosis, Prospective Studies
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:19
Last Modified : 17 May 2017 10:19
URI: http://epubs.surrey.ac.uk/id/eprint/827283

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