University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Effects of long-term exposure to air pollution on natural-cause mortality: an analysis of 22 European cohorts within the multicentre ESCAPE project.

Beelen, R, Raaschou-Nielsen, O, Stafoggia, M, Andersen, ZJ, Weinmayr, G, Hoffmann, B, Wolf, K, Samoli, E, Fischer, P, Nieuwenhuijsen, M , Vineis, P, Xun, WW, Katsouyanni, K, Dimakopoulou, K, Oudin, A, Forsberg, B, Modig, L, Havulinna, AS, Lanki, T, Turunen, A, Oftedal, B, Nystad, W, Nafstad, P, De Faire, U, Pedersen, NL, Östenson, CG, Fratiglioni, L, Penell, J, Korek, M, Pershagen, G, Eriksen, KT, Overvad, K, Ellermann, T, Eeftens, M, Peeters, PH, Meliefste, K, Wang, M, Bueno-de-Mesquita, B, Sugiri, D, Krämer, U, Heinrich, J, de Hoogh, K, Key, T, Peters, A, Hampel, R, Concin, H, Nagel, G, Ineichen, A, Schaffner, E, Probst-Hensch, N, Künzli, N, Schindler, C, Schikowski, T, Adam, M, Phuleria, H, Vilier, A, Clavel-Chapelon, F, Declercq, C, Grioni, S, Krogh, V, Tsai, MY, Ricceri, F, Sacerdote, C, Galassi, C, Migliore, E, Ranzi, A, Cesaroni, G, Badaloni, C, Forastiere, F, Tamayo, I, Amiano, P, Dorronsoro, M, Katsoulis, M, Trichopoulou, A, Brunekreef, B and Hoek, G (2014) Effects of long-term exposure to air pollution on natural-cause mortality: an analysis of 22 European cohorts within the multicentre ESCAPE project. Lancet, 383 (9919). pp. 785-795.

Full text not available from this repository.

Abstract

BACKGROUND: Few studies on long-term exposure to air pollution and mortality have been reported from Europe. Within the multicentre European Study of Cohorts for Air Pollution Effects (ESCAPE), we aimed to investigate the association between natural-cause mortality and long-term exposure to several air pollutants. METHODS: We used data from 22 European cohort studies, which created a total study population of 367,251 participants. All cohorts were general population samples, although some were restricted to one sex only. With a strictly standardised protocol, we assessed residential exposure to air pollutants as annual average concentrations of particulate matter (PM) with diameters of less than 2.5 μm (PM2.5), less than 10 μm (PM10), and between 10 μm and 2.5 μm (PMcoarse), PM2.5 absorbance, and annual average concentrations of nitrogen oxides (NO2 and NOx), with land use regression models. We also investigated two traffic intensity variables-traffic intensity on the nearest road (vehicles per day) and total traffic load on all major roads within a 100 m buffer. We did cohort-specific statistical analyses using confounder models with increasing adjustment for confounder variables, and Cox proportional hazards models with a common protocol. We obtained pooled effect estimates through a random-effects meta-analysis. FINDINGS: The total study population consisted of 367,251 participants who contributed 5,118,039 person-years at risk (average follow-up 13.9 years), of whom 29,076 died from a natural cause during follow-up. A significantly increased hazard ratio (HR) for PM2.5 of 1.07 (95% CI 1.02-1.13) per 5 μg/m(3) was recorded. No heterogeneity was noted between individual cohort effect estimates (I(2) p value=0.95). HRs for PM2.5 remained significantly raised even when we included only participants exposed to pollutant concentrations lower than the European annual mean limit value of 25 μg/m(3) (HR 1.06, 95% CI 1.00-1.12) or below 20 μg/m(3) (1.07, 1.01-1.13). INTERPRETATION: Long-term exposure to fine particulate air pollution was associated with natural-cause mortality, even within concentration ranges well below the present European annual mean limit value. FUNDING: European Community's Seventh Framework Program (FP7/2007-2011).

Item Type: Article
Authors :
NameEmailORCID
Beelen, RUNSPECIFIEDUNSPECIFIED
Raaschou-Nielsen, OUNSPECIFIEDUNSPECIFIED
Stafoggia, MUNSPECIFIEDUNSPECIFIED
Andersen, ZJUNSPECIFIEDUNSPECIFIED
Weinmayr, GUNSPECIFIEDUNSPECIFIED
Hoffmann, BUNSPECIFIEDUNSPECIFIED
Wolf, KUNSPECIFIEDUNSPECIFIED
Samoli, EUNSPECIFIEDUNSPECIFIED
Fischer, PUNSPECIFIEDUNSPECIFIED
Nieuwenhuijsen, MUNSPECIFIEDUNSPECIFIED
Vineis, PUNSPECIFIEDUNSPECIFIED
Xun, WWUNSPECIFIEDUNSPECIFIED
Katsouyanni, KUNSPECIFIEDUNSPECIFIED
Dimakopoulou, KUNSPECIFIEDUNSPECIFIED
Oudin, AUNSPECIFIEDUNSPECIFIED
Forsberg, BUNSPECIFIEDUNSPECIFIED
Modig, LUNSPECIFIEDUNSPECIFIED
Havulinna, ASUNSPECIFIEDUNSPECIFIED
Lanki, TUNSPECIFIEDUNSPECIFIED
Turunen, AUNSPECIFIEDUNSPECIFIED
Oftedal, BUNSPECIFIEDUNSPECIFIED
Nystad, WUNSPECIFIEDUNSPECIFIED
Nafstad, PUNSPECIFIEDUNSPECIFIED
De Faire, UUNSPECIFIEDUNSPECIFIED
Pedersen, NLUNSPECIFIEDUNSPECIFIED
Östenson, CGUNSPECIFIEDUNSPECIFIED
Fratiglioni, LUNSPECIFIEDUNSPECIFIED
Penell, Jj.penell@surrey.ac.ukUNSPECIFIED
Korek, MUNSPECIFIEDUNSPECIFIED
Pershagen, GUNSPECIFIEDUNSPECIFIED
Eriksen, KTUNSPECIFIEDUNSPECIFIED
Overvad, KUNSPECIFIEDUNSPECIFIED
Ellermann, TUNSPECIFIEDUNSPECIFIED
Eeftens, MUNSPECIFIEDUNSPECIFIED
Peeters, PHUNSPECIFIEDUNSPECIFIED
Meliefste, KUNSPECIFIEDUNSPECIFIED
Wang, MUNSPECIFIEDUNSPECIFIED
Bueno-de-Mesquita, BUNSPECIFIEDUNSPECIFIED
Sugiri, DUNSPECIFIEDUNSPECIFIED
Krämer, UUNSPECIFIEDUNSPECIFIED
Heinrich, JUNSPECIFIEDUNSPECIFIED
de Hoogh, KUNSPECIFIEDUNSPECIFIED
Key, TUNSPECIFIEDUNSPECIFIED
Peters, AUNSPECIFIEDUNSPECIFIED
Hampel, RUNSPECIFIEDUNSPECIFIED
Concin, HUNSPECIFIEDUNSPECIFIED
Nagel, GUNSPECIFIEDUNSPECIFIED
Ineichen, AUNSPECIFIEDUNSPECIFIED
Schaffner, EUNSPECIFIEDUNSPECIFIED
Probst-Hensch, NUNSPECIFIEDUNSPECIFIED
Künzli, NUNSPECIFIEDUNSPECIFIED
Schindler, CUNSPECIFIEDUNSPECIFIED
Schikowski, TUNSPECIFIEDUNSPECIFIED
Adam, MUNSPECIFIEDUNSPECIFIED
Phuleria, HUNSPECIFIEDUNSPECIFIED
Vilier, AUNSPECIFIEDUNSPECIFIED
Clavel-Chapelon, FUNSPECIFIEDUNSPECIFIED
Declercq, CUNSPECIFIEDUNSPECIFIED
Grioni, SUNSPECIFIEDUNSPECIFIED
Krogh, VUNSPECIFIEDUNSPECIFIED
Tsai, MYUNSPECIFIEDUNSPECIFIED
Ricceri, FUNSPECIFIEDUNSPECIFIED
Sacerdote, CUNSPECIFIEDUNSPECIFIED
Galassi, CUNSPECIFIEDUNSPECIFIED
Migliore, EUNSPECIFIEDUNSPECIFIED
Ranzi, AUNSPECIFIEDUNSPECIFIED
Cesaroni, GUNSPECIFIEDUNSPECIFIED
Badaloni, CUNSPECIFIEDUNSPECIFIED
Forastiere, FUNSPECIFIEDUNSPECIFIED
Tamayo, IUNSPECIFIEDUNSPECIFIED
Amiano, PUNSPECIFIEDUNSPECIFIED
Dorronsoro, MUNSPECIFIEDUNSPECIFIED
Katsoulis, MUNSPECIFIEDUNSPECIFIED
Trichopoulou, AUNSPECIFIEDUNSPECIFIED
Brunekreef, BUNSPECIFIEDUNSPECIFIED
Hoek, GUNSPECIFIEDUNSPECIFIED
Date : 1 March 2014
Identification Number : 10.1016/S0140-6736(13)62158-3
Uncontrolled Keywords : Adolescent, Adult, Aged, Air Pollutants, Air Pollution, Cause of Death, Child, Child, Preschool, Cohort Studies, Environmental Exposure, Europe, Female, Humans, Infant, Male, Middle Aged, Multicenter Studies as Topic, Particulate Matter, Young Adult
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:19
Last Modified : 17 May 2017 10:19
URI: http://epubs.surrey.ac.uk/id/eprint/827281

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800