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Air pollution and nonmalignant respiratory mortality in 16 cohorts within the ESCAPE project.

Dimakopoulou, K, Samoli, E, Beelen, R, Stafoggia, M, Andersen, ZJ, Hoffmann, B, Fischer, P, Nieuwenhuijsen, M, Vineis, P, Xun, W, Hoek, G, Raaschou-Nielsen, O, Oudin, A, Forsberg, B, Modig, L, Jousilahti, P, Lanki, T, Turunen, A, Oftedal, B, Nafstad, P, Schwarze, PE, Penell, J, Fratiglioni, L, Andersson, N, Pedersen, N, Korek, M, De Faire, U, Eriksen, KT, Tjønneland, A, Becker, T, Wang, M, Bueno-de-Mesquita, B, Tsai, MY, Eeftens, M, Peeters, PH, Meliefste, K, Marcon, A, Krämer, U, Kuhlbusch, TA, Vossoughi, M, Key, T, de Hoogh, K, Hampel, R, Peters, A, Heinrich, J, Weinmayr, G, Concin, H, Nagel, G, Ineichen, A, Jacquemin, B, Stempfelet, M, Vilier, A, Ricceri, F, Sacerdote, C, Pedeli, X, Katsoulis, M, Trichopoulou, A, Brunekreef, B and Katsouyanni, K (2014) Air pollution and nonmalignant respiratory mortality in 16 cohorts within the ESCAPE project. Am J Respir Crit Care Med, 189 (6). pp. 684-696.

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Abstract

RATIONALE: Prospective cohort studies have shown that chronic exposure to particulate matter and traffic-related air pollution is associated with reduced survival. However, the effects on nonmalignant respiratory mortality are less studied, and the data reported are less consistent. OBJECTIVES: We have investigated the relationship of long-term exposure to air pollution and nonmalignant respiratory mortality in 16 cohorts with individual level data within the multicenter European Study of Cohorts for Air Pollution Effects (ESCAPE). METHODS: Data from 16 ongoing cohort studies from Europe were used. The total number of subjects was 307,553. There were 1,559 respiratory deaths during follow-up. MEASUREMENTS AND MAIN RESULTS: Air pollution exposure was estimated by land use regression models at the baseline residential addresses of study participants and traffic-proximity variables were derived from geographical databases following a standardized procedure within the ESCAPE study. Cohort-specific hazard ratios obtained by Cox proportional hazard models from standardized individual cohort analyses were combined using metaanalyses. We found no significant associations between air pollution exposure and nonmalignant respiratory mortality. Most hazard ratios were slightly below unity, with the exception of the traffic-proximity indicators. CONCLUSIONS: In this study of 16 cohorts, there was no association between air pollution exposure and nonmalignant respiratory mortality.

Item Type: Article
Authors :
NameEmailORCID
Dimakopoulou, KUNSPECIFIEDUNSPECIFIED
Samoli, EUNSPECIFIEDUNSPECIFIED
Beelen, RUNSPECIFIEDUNSPECIFIED
Stafoggia, MUNSPECIFIEDUNSPECIFIED
Andersen, ZJUNSPECIFIEDUNSPECIFIED
Hoffmann, BUNSPECIFIEDUNSPECIFIED
Fischer, PUNSPECIFIEDUNSPECIFIED
Nieuwenhuijsen, MUNSPECIFIEDUNSPECIFIED
Vineis, PUNSPECIFIEDUNSPECIFIED
Xun, WUNSPECIFIEDUNSPECIFIED
Hoek, GUNSPECIFIEDUNSPECIFIED
Raaschou-Nielsen, OUNSPECIFIEDUNSPECIFIED
Oudin, AUNSPECIFIEDUNSPECIFIED
Forsberg, BUNSPECIFIEDUNSPECIFIED
Modig, LUNSPECIFIEDUNSPECIFIED
Jousilahti, PUNSPECIFIEDUNSPECIFIED
Lanki, TUNSPECIFIEDUNSPECIFIED
Turunen, AUNSPECIFIEDUNSPECIFIED
Oftedal, BUNSPECIFIEDUNSPECIFIED
Nafstad, PUNSPECIFIEDUNSPECIFIED
Schwarze, PEUNSPECIFIEDUNSPECIFIED
Penell, Jj.penell@surrey.ac.ukUNSPECIFIED
Fratiglioni, LUNSPECIFIEDUNSPECIFIED
Andersson, NUNSPECIFIEDUNSPECIFIED
Pedersen, NUNSPECIFIEDUNSPECIFIED
Korek, MUNSPECIFIEDUNSPECIFIED
De Faire, UUNSPECIFIEDUNSPECIFIED
Eriksen, KTUNSPECIFIEDUNSPECIFIED
Tjønneland, AUNSPECIFIEDUNSPECIFIED
Becker, TUNSPECIFIEDUNSPECIFIED
Wang, MUNSPECIFIEDUNSPECIFIED
Bueno-de-Mesquita, BUNSPECIFIEDUNSPECIFIED
Tsai, MYUNSPECIFIEDUNSPECIFIED
Eeftens, MUNSPECIFIEDUNSPECIFIED
Peeters, PHUNSPECIFIEDUNSPECIFIED
Meliefste, KUNSPECIFIEDUNSPECIFIED
Marcon, AUNSPECIFIEDUNSPECIFIED
Krämer, UUNSPECIFIEDUNSPECIFIED
Kuhlbusch, TAUNSPECIFIEDUNSPECIFIED
Vossoughi, MUNSPECIFIEDUNSPECIFIED
Key, TUNSPECIFIEDUNSPECIFIED
de Hoogh, KUNSPECIFIEDUNSPECIFIED
Hampel, RUNSPECIFIEDUNSPECIFIED
Peters, AUNSPECIFIEDUNSPECIFIED
Heinrich, JUNSPECIFIEDUNSPECIFIED
Weinmayr, GUNSPECIFIEDUNSPECIFIED
Concin, HUNSPECIFIEDUNSPECIFIED
Nagel, GUNSPECIFIEDUNSPECIFIED
Ineichen, AUNSPECIFIEDUNSPECIFIED
Jacquemin, BUNSPECIFIEDUNSPECIFIED
Stempfelet, MUNSPECIFIEDUNSPECIFIED
Vilier, AUNSPECIFIEDUNSPECIFIED
Ricceri, FUNSPECIFIEDUNSPECIFIED
Sacerdote, CUNSPECIFIEDUNSPECIFIED
Pedeli, XUNSPECIFIEDUNSPECIFIED
Katsoulis, MUNSPECIFIEDUNSPECIFIED
Trichopoulou, AUNSPECIFIEDUNSPECIFIED
Brunekreef, BUNSPECIFIEDUNSPECIFIED
Katsouyanni, KUNSPECIFIEDUNSPECIFIED
Date : 15 March 2014
Identification Number : https://doi.org/10.1164/rccm.201310-1777OC
Uncontrolled Keywords : Adult, Aged, Aged, 80 and over, Air Pollutants, Air Pollution, Cohort Studies, Environmental Exposure, Europe, Female, Follow-Up Studies, Humans, Male, Middle Aged, Particulate Matter, Proportional Hazards Models, Regression Analysis, Respiratory Tract Diseases
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:18
Last Modified : 17 May 2017 10:18
URI: http://epubs.surrey.ac.uk/id/eprint/827279

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