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Circulating levels of p,p'-DDE are related to prevalent hypertension in the elderly.

Lind, PM, Penell, J, Salihovic, S, van Bavel, B and Lind, L (2014) Circulating levels of p,p'-DDE are related to prevalent hypertension in the elderly. Environ Res, 129. pp. 27-31.

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BACKGROUND: Polychlorinated biphenyls (PCBs) and dioxin given to experimental animals increase the blood pressure. We therefore investigated if circulating levels of persistent organic pollutants (POPs) were related to hypertension in a population-based sample of men and women. METHODS: One thousand and sixteen subjects aged 70 years were investigated in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Twenty-three POPs were analyzed using high-resolution gas chromatography/high-resolution mass spectrometry (HRGC/HRMS). Hypertension was defined as a systolic blood pressure ≥140mmHg or a diastolic blood pressure ≥90mmHg, and/or use of antihypertensive medication. RESULTS: Seven hundred and thirty-two subjects (72%) showed hypertension. When the POPs were treated as continuous variables and adjusted for gender only, two PCBs with a low number of chlorine atoms (PCB 105 and 118) were related to prevalent hypertension. Also the OC pesticide p,p'-DDE was related to hypertension. The strongest of these associations was seen for p,p'-DDE (OR 1.35 for a 1 SD change, 95% CI 1.17-1.56, p<0.0001). Following further adjustment also for BMI, smoking status, education level and exercise habits, only p,p'-DDE was still significantly related to hypertension (OR 1.23 for a 1 SD change, 95% CI 1.06-1.43, p=0.006). CONCLUSION: In this cross-sectional analysis of an elderly population, high levels of circulating levels of p,p'-DDE were associated with prevalent hypertension, further strengthening the experimental findings that POPs might influence blood pressure.

Item Type: Article
Divisions : Surrey research (other units)
Authors :
Lind, PM
Salihovic, S
van Bavel, B
Lind, L
Date : February 2014
DOI : 10.1016/j.envres.2013.12.003
Uncontrolled Keywords : DDE, Elderly, Hypertension, Persistent organic pollutants, Polychlorinated biphenyls, Aged, Cross-Sectional Studies, Data Interpretation, Statistical, Dichlorodiphenyl Dichloroethylene, Environmental Monitoring, Environmental Pollutants, Female, Humans, Hypertension, Male, Prevalence, Prospective Studies, Surveys and Questionnaires, Sweden
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:18
Last Modified : 24 Jan 2020 18:58

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