University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Long-term exposure to elemental constituents of particulate matter and cardiovascular mortality in 19 European cohorts: results from the ESCAPE and TRANSPHORM projects.

Wang, M, Beelen, R, Stafoggia, M, Raaschou-Nielsen, O, Andersen, ZJ, Hoffmann, B, Fischer, P, Houthuijs, D, Nieuwenhuijsen, M, Weinmayr, G , Vineis, P, Xun, WW, Dimakopoulou, K, Samoli, E, Laatikainen, T, Lanki, T, Turunen, AW, Oftedal, B, Schwarze, P, Aamodt, G, Penell, J, De Faire, U, Korek, M, Leander, K, Pershagen, G, Pedersen, NL, Östenson, CG, Fratiglioni, L, Eriksen, KT, Sørensen, M, Tjønneland, A, Bueno-de-Mesquita, B, Eeftens, M, Bots, ML, Meliefste, K, Krämer, U, Heinrich, J, Sugiri, D, Key, T, de Hoogh, K, Wolf, K, Peters, A, Cyrys, J, Jaensch, A, Concin, H, Nagel, G, Tsai, MY, Phuleria, H, Ineichen, A, Künzli, N, Probst-Hensch, N, Schaffner, E, Vilier, A, Clavel-Chapelon, F, Declerq, C, Ricceri, F, Sacerdote, C, Marcon, A, Galassi, C, Migliore, E, Ranzi, A, Cesaroni, G, Badaloni, C, Forastiere, F, Katsoulis, M, Trichopoulou, A, Keuken, M, Jedynska, A, Kooter, IM, Kukkonen, J, Sokhi, RS, Brunekreef, B, Katsouyanni, K and Hoek, G (2014) Long-term exposure to elemental constituents of particulate matter and cardiovascular mortality in 19 European cohorts: results from the ESCAPE and TRANSPHORM projects. Environ Int, 66. pp. 97-106.

Full text not available from this repository.

Abstract

BACKGROUND: Associations between long-term exposure to ambient particulate matter (PM) and cardiovascular (CVD) mortality have been widely recognized. However, health effects of long-term exposure to constituents of PM on total CVD mortality have been explored in a single study only. AIMS: The aim of this study was to examine the association of PM composition with cardiovascular mortality. METHODS: We used data from 19 European ongoing cohorts within the framework of the ESCAPE (European Study of Cohorts for Air Pollution Effects) and TRANSPHORM (Transport related Air Pollution and Health impacts--Integrated Methodologies for Assessing Particulate Matter) projects. Residential annual average exposure to elemental constituents within particle matter smaller than 2.5 and 10 μm (PM2.5 and PM10) was estimated using Land Use Regression models. Eight elements representing major sources were selected a priori (copper, iron, potassium, nickel, sulfur, silicon, vanadium and zinc). Cohort-specific analyses were conducted using Cox proportional hazards models with a standardized protocol. Random-effects meta-analysis was used to calculate combined effect estimates. RESULTS: The total population consisted of 322,291 participants, with 9545 CVD deaths. We found no statistically significant associations between any of the elemental constituents in PM2.5 or PM10 and CVD mortality in the pooled analysis. Most of the hazard ratios (HRs) were close to unity, e.g. for PM10 Fe the combined HR was 0.96 (0.84-1.09). Elevated combined HRs were found for PM2.5 Si (1.17, 95% CI: 0.93-1.47), and S in PM2.5 (1.08, 95% CI: 0.95-1.22) and PM10 (1.09, 95% CI: 0.90-1.32). CONCLUSION: In a joint analysis of 19 European cohorts, we found no statistically significant association between long-term exposure to 8 elemental constituents of particles and total cardiovascular mortality.

Item Type: Article
Authors :
NameEmailORCID
Wang, MUNSPECIFIEDUNSPECIFIED
Beelen, RUNSPECIFIEDUNSPECIFIED
Stafoggia, MUNSPECIFIEDUNSPECIFIED
Raaschou-Nielsen, OUNSPECIFIEDUNSPECIFIED
Andersen, ZJUNSPECIFIEDUNSPECIFIED
Hoffmann, BUNSPECIFIEDUNSPECIFIED
Fischer, PUNSPECIFIEDUNSPECIFIED
Houthuijs, DUNSPECIFIEDUNSPECIFIED
Nieuwenhuijsen, MUNSPECIFIEDUNSPECIFIED
Weinmayr, GUNSPECIFIEDUNSPECIFIED
Vineis, PUNSPECIFIEDUNSPECIFIED
Xun, WWUNSPECIFIEDUNSPECIFIED
Dimakopoulou, KUNSPECIFIEDUNSPECIFIED
Samoli, EUNSPECIFIEDUNSPECIFIED
Laatikainen, TUNSPECIFIEDUNSPECIFIED
Lanki, TUNSPECIFIEDUNSPECIFIED
Turunen, AWUNSPECIFIEDUNSPECIFIED
Oftedal, BUNSPECIFIEDUNSPECIFIED
Schwarze, PUNSPECIFIEDUNSPECIFIED
Aamodt, GUNSPECIFIEDUNSPECIFIED
Penell, Jj.penell@surrey.ac.ukUNSPECIFIED
De Faire, UUNSPECIFIEDUNSPECIFIED
Korek, MUNSPECIFIEDUNSPECIFIED
Leander, KUNSPECIFIEDUNSPECIFIED
Pershagen, GUNSPECIFIEDUNSPECIFIED
Pedersen, NLUNSPECIFIEDUNSPECIFIED
Östenson, CGUNSPECIFIEDUNSPECIFIED
Fratiglioni, LUNSPECIFIEDUNSPECIFIED
Eriksen, KTUNSPECIFIEDUNSPECIFIED
Sørensen, MUNSPECIFIEDUNSPECIFIED
Tjønneland, AUNSPECIFIEDUNSPECIFIED
Bueno-de-Mesquita, BUNSPECIFIEDUNSPECIFIED
Eeftens, MUNSPECIFIEDUNSPECIFIED
Bots, MLUNSPECIFIEDUNSPECIFIED
Meliefste, KUNSPECIFIEDUNSPECIFIED
Krämer, UUNSPECIFIEDUNSPECIFIED
Heinrich, JUNSPECIFIEDUNSPECIFIED
Sugiri, DUNSPECIFIEDUNSPECIFIED
Key, TUNSPECIFIEDUNSPECIFIED
de Hoogh, KUNSPECIFIEDUNSPECIFIED
Wolf, KUNSPECIFIEDUNSPECIFIED
Peters, AUNSPECIFIEDUNSPECIFIED
Cyrys, JUNSPECIFIEDUNSPECIFIED
Jaensch, AUNSPECIFIEDUNSPECIFIED
Concin, HUNSPECIFIEDUNSPECIFIED
Nagel, GUNSPECIFIEDUNSPECIFIED
Tsai, MYUNSPECIFIEDUNSPECIFIED
Phuleria, HUNSPECIFIEDUNSPECIFIED
Ineichen, AUNSPECIFIEDUNSPECIFIED
Künzli, NUNSPECIFIEDUNSPECIFIED
Probst-Hensch, NUNSPECIFIEDUNSPECIFIED
Schaffner, EUNSPECIFIEDUNSPECIFIED
Vilier, AUNSPECIFIEDUNSPECIFIED
Clavel-Chapelon, FUNSPECIFIEDUNSPECIFIED
Declerq, CUNSPECIFIEDUNSPECIFIED
Ricceri, FUNSPECIFIEDUNSPECIFIED
Sacerdote, CUNSPECIFIEDUNSPECIFIED
Marcon, AUNSPECIFIEDUNSPECIFIED
Galassi, CUNSPECIFIEDUNSPECIFIED
Migliore, EUNSPECIFIEDUNSPECIFIED
Ranzi, AUNSPECIFIEDUNSPECIFIED
Cesaroni, GUNSPECIFIEDUNSPECIFIED
Badaloni, CUNSPECIFIEDUNSPECIFIED
Forastiere, FUNSPECIFIEDUNSPECIFIED
Katsoulis, MUNSPECIFIEDUNSPECIFIED
Trichopoulou, AUNSPECIFIEDUNSPECIFIED
Keuken, MUNSPECIFIEDUNSPECIFIED
Jedynska, AUNSPECIFIEDUNSPECIFIED
Kooter, IMUNSPECIFIEDUNSPECIFIED
Kukkonen, JUNSPECIFIEDUNSPECIFIED
Sokhi, RSUNSPECIFIEDUNSPECIFIED
Brunekreef, BUNSPECIFIEDUNSPECIFIED
Katsouyanni, KUNSPECIFIEDUNSPECIFIED
Hoek, GUNSPECIFIEDUNSPECIFIED
Date : May 2014
Identification Number : 10.1016/j.envint.2014.01.026
Uncontrolled Keywords : Cardiovascular mortality, Constituents, ESCAPE, Long-term exposure, Particulate matter, TRANSPHORM, Adult, Aged, Cardiovascular Diseases, Cohort Studies, Environmental Exposure, Europe, Female, Humans, Male, Middle Aged, Particulate Matter, Proportional Hazards Models
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:18
Last Modified : 17 May 2017 10:18
URI: http://epubs.surrey.ac.uk/id/eprint/827277

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800