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Long-term exposure to air pollution and cardiovascular mortality: an analysis of 22 European cohorts.

Beelen, R, Stafoggia, M, Raaschou-Nielsen, O, Andersen, ZJ, Xun, WW, Katsouyanni, K, Dimakopoulou, K, Brunekreef, B, Weinmayr, G, Hoffmann, B , Wolf, K, Samoli, E, Houthuijs, D, Nieuwenhuijsen, M, Oudin, A, Forsberg, B, Olsson, D, Salomaa, V, Lanki, T, Yli-Tuomi, T, Oftedal, B, Aamodt, G, Nafstad, P, De Faire, U, Pedersen, NL, Östenson, CG, Fratiglioni, L, Penell, J, Korek, M, Pyko, A, Eriksen, KT, Tjønneland, A, Becker, T, Eeftens, M, Bots, M, Meliefste, K, Wang, M, Bueno-de-Mesquita, B, Sugiri, D, Krämer, U, Heinrich, J, de Hoogh, K, Key, T, Peters, A, Cyrys, J, Concin, H, Nagel, G, Ineichen, A, Schaffner, E, Probst-Hensch, N, Dratva, J, Ducret-Stich, R, Vilier, A, Clavel-Chapelon, F, Stempfelet, M, Grioni, S, Krogh, V, Tsai, MY, Marcon, A, Ricceri, F, Sacerdote, C, Galassi, C, Migliore, E, Ranzi, A, Cesaroni, G, Badaloni, C, Forastiere, F, Tamayo, I, Amiano, P, Dorronsoro, M, Katsoulis, M, Trichopoulou, A, Vineis, P and Hoek, G (2014) Long-term exposure to air pollution and cardiovascular mortality: an analysis of 22 European cohorts. Epidemiology, 25 (3). pp. 368-378.

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Abstract

BACKGROUND: Air pollution has been associated with cardiovascular mortality, but it remains unclear as to whether specific pollutants are related to specific cardiovascular causes of death. Within the multicenter European Study of Cohorts for Air Pollution Effects (ESCAPE), we investigated the associations of long-term exposure to several air pollutants with all cardiovascular disease (CVD) mortality, as well as with specific cardiovascular causes of death. METHODS: Data from 22 European cohort studies were used. Using a standardized protocol, study area-specific air pollution exposure at the residential address was characterized as annual average concentrations of the following: nitrogen oxides (NO2 and NOx); particles with diameters of less than 2.5 μm (PM2.5), less than 10 μm (PM10), and 10 μm to 2.5 μm (PMcoarse); PM2.5 absorbance estimated by land-use regression models; and traffic indicators. We applied cohort-specific Cox proportional hazards models using a standardized protocol. Random-effects meta-analysis was used to obtain pooled effect estimates. RESULTS: The total study population consisted of 367,383 participants, with 9994 deaths from CVD (including 4,992 from ischemic heart disease, 2264 from myocardial infarction, and 2484 from cerebrovascular disease). All hazard ratios were approximately 1.0, except for particle mass and cerebrovascular disease mortality; for PM2.5, the hazard ratio was 1.21 (95% confidence interval = 0.87-1.69) per 5 μg/m and for PM10, 1.22 (0.91-1.63) per 10 μg/m. CONCLUSION: In a joint analysis of data from 22 European cohorts, most hazard ratios for the association of air pollutants with mortality from overall CVD and with specific CVDs were approximately 1.0, with the exception of particulate mass and cerebrovascular disease mortality for which there was suggestive evidence for an association.

Item Type: Article
Authors :
NameEmailORCID
Beelen, RUNSPECIFIEDUNSPECIFIED
Stafoggia, MUNSPECIFIEDUNSPECIFIED
Raaschou-Nielsen, OUNSPECIFIEDUNSPECIFIED
Andersen, ZJUNSPECIFIEDUNSPECIFIED
Xun, WWUNSPECIFIEDUNSPECIFIED
Katsouyanni, KUNSPECIFIEDUNSPECIFIED
Dimakopoulou, KUNSPECIFIEDUNSPECIFIED
Brunekreef, BUNSPECIFIEDUNSPECIFIED
Weinmayr, GUNSPECIFIEDUNSPECIFIED
Hoffmann, BUNSPECIFIEDUNSPECIFIED
Wolf, KUNSPECIFIEDUNSPECIFIED
Samoli, EUNSPECIFIEDUNSPECIFIED
Houthuijs, DUNSPECIFIEDUNSPECIFIED
Nieuwenhuijsen, MUNSPECIFIEDUNSPECIFIED
Oudin, AUNSPECIFIEDUNSPECIFIED
Forsberg, BUNSPECIFIEDUNSPECIFIED
Olsson, DUNSPECIFIEDUNSPECIFIED
Salomaa, VUNSPECIFIEDUNSPECIFIED
Lanki, TUNSPECIFIEDUNSPECIFIED
Yli-Tuomi, TUNSPECIFIEDUNSPECIFIED
Oftedal, BUNSPECIFIEDUNSPECIFIED
Aamodt, GUNSPECIFIEDUNSPECIFIED
Nafstad, PUNSPECIFIEDUNSPECIFIED
De Faire, UUNSPECIFIEDUNSPECIFIED
Pedersen, NLUNSPECIFIEDUNSPECIFIED
Östenson, CGUNSPECIFIEDUNSPECIFIED
Fratiglioni, LUNSPECIFIEDUNSPECIFIED
Penell, Jj.penell@surrey.ac.ukUNSPECIFIED
Korek, MUNSPECIFIEDUNSPECIFIED
Pyko, AUNSPECIFIEDUNSPECIFIED
Eriksen, KTUNSPECIFIEDUNSPECIFIED
Tjønneland, AUNSPECIFIEDUNSPECIFIED
Becker, TUNSPECIFIEDUNSPECIFIED
Eeftens, MUNSPECIFIEDUNSPECIFIED
Bots, MUNSPECIFIEDUNSPECIFIED
Meliefste, KUNSPECIFIEDUNSPECIFIED
Wang, MUNSPECIFIEDUNSPECIFIED
Bueno-de-Mesquita, BUNSPECIFIEDUNSPECIFIED
Sugiri, DUNSPECIFIEDUNSPECIFIED
Krämer, UUNSPECIFIEDUNSPECIFIED
Heinrich, JUNSPECIFIEDUNSPECIFIED
de Hoogh, KUNSPECIFIEDUNSPECIFIED
Key, TUNSPECIFIEDUNSPECIFIED
Peters, AUNSPECIFIEDUNSPECIFIED
Cyrys, JUNSPECIFIEDUNSPECIFIED
Concin, HUNSPECIFIEDUNSPECIFIED
Nagel, GUNSPECIFIEDUNSPECIFIED
Ineichen, AUNSPECIFIEDUNSPECIFIED
Schaffner, EUNSPECIFIEDUNSPECIFIED
Probst-Hensch, NUNSPECIFIEDUNSPECIFIED
Dratva, JUNSPECIFIEDUNSPECIFIED
Ducret-Stich, RUNSPECIFIEDUNSPECIFIED
Vilier, AUNSPECIFIEDUNSPECIFIED
Clavel-Chapelon, FUNSPECIFIEDUNSPECIFIED
Stempfelet, MUNSPECIFIEDUNSPECIFIED
Grioni, SUNSPECIFIEDUNSPECIFIED
Krogh, VUNSPECIFIEDUNSPECIFIED
Tsai, MYUNSPECIFIEDUNSPECIFIED
Marcon, AUNSPECIFIEDUNSPECIFIED
Ricceri, FUNSPECIFIEDUNSPECIFIED
Sacerdote, CUNSPECIFIEDUNSPECIFIED
Galassi, CUNSPECIFIEDUNSPECIFIED
Migliore, EUNSPECIFIEDUNSPECIFIED
Ranzi, AUNSPECIFIEDUNSPECIFIED
Cesaroni, GUNSPECIFIEDUNSPECIFIED
Badaloni, CUNSPECIFIEDUNSPECIFIED
Forastiere, FUNSPECIFIEDUNSPECIFIED
Tamayo, IUNSPECIFIEDUNSPECIFIED
Amiano, PUNSPECIFIEDUNSPECIFIED
Dorronsoro, MUNSPECIFIEDUNSPECIFIED
Katsoulis, MUNSPECIFIEDUNSPECIFIED
Trichopoulou, AUNSPECIFIEDUNSPECIFIED
Vineis, PUNSPECIFIEDUNSPECIFIED
Hoek, GUNSPECIFIEDUNSPECIFIED
Date : May 2014
Identification Number : 10.1097/EDE.0000000000000076
Uncontrolled Keywords : Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Air Pollutants, Air Pollution, Cardiovascular Diseases, Cause of Death, Cohort Studies, Databases, Factual, Environmental Exposure, Europe, Female, Humans, Incidence, Male, Middle Aged, Nitric Oxide, Particulate Matter, Proportional Hazards Models, Sex Distribution, Time Factors, Young Adult
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:18
Last Modified : 17 May 2017 10:18
URI: http://epubs.surrey.ac.uk/id/eprint/827276

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