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Long-term exposure to ambient air pollution and incidence of cerebrovascular events: results from 11 European cohorts within the ESCAPE project.

Stafoggia, M, Cesaroni, G, Peters, A, Andersen, ZJ, Badaloni, C, Beelen, R, Caracciolo, B, Cyrys, J, de Faire, U, de Hoogh, K , Eriksen, KT, Fratiglioni, L, Galassi, C, Gigante, B, Havulinna, AS, Hennig, F, Hilding, A, Hoek, G, Hoffmann, B, Houthuijs, D, Korek, M, Lanki, T, Leander, K, Magnusson, PK, Meisinger, C, Migliore, E, Overvad, K, Ostenson, CG, Pedersen, NL, Pekkanen, J, Penell, J, Pershagen, G, Pundt, N, Pyko, A, Raaschou-Nielsen, O, Ranzi, A, Ricceri, F, Sacerdote, C, Swart, WJ, Turunen, AW, Vineis, P, Weimar, C, Weinmayr, G, Wolf, K, Brunekreef, B and Forastiere, F (2014) Long-term exposure to ambient air pollution and incidence of cerebrovascular events: results from 11 European cohorts within the ESCAPE project. Environ Health Perspect, 122 (9). pp. 919-925.

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Abstract

BACKGROUND: Few studies have investigated effects of air pollution on the incidence of cerebrovascular events. OBJECTIVES: We assessed the association between long-term exposure to multiple air pollutants and the incidence of stroke in European cohorts. METHODS: Data from 11 cohorts were collected, and occurrence of a first stroke was evaluated. Individual air pollution exposures were predicted from land-use regression models developed within the European Study of Cohorts for Air Pollution Effects (ESCAPE). The exposures were: PM2.5 [particulate matter (PM) ≤ 2.5 μm in diameter], coarse PM (PM between 2.5 and 10 μm), PM10 (PM ≤ 10 μm), PM2.5 absorbance, nitrogen oxides, and two traffic indicators. Cohort-specific analyses were conducted using Cox proportional hazards models. Random-effects meta-analysis was used for pooled effect estimation. RESULTS: A total of 99,446 study participants were included, 3,086 of whom developed stroke. A 5-μg/m3 increase in annual PM2.5 exposure was associated with 19% increased risk of incident stroke [hazard ratio (HR) = 1.19, 95% CI: 0.88, 1.62]. Similar findings were obtained for PM10. The results were robust to adjustment for an extensive list of cardiovascular risk factors and noise coexposure. The association with PM2.5 was apparent among those ≥ 60 years of age (HR = 1.40, 95% CI: 1.05, 1.87), among never-smokers (HR = 1.74, 95% CI: 1.06, 2.88), and among participants with PM2.5 exposure < 25 μg/m3 (HR = 1.33, 95% CI: 1.01, 1.77). CONCLUSIONS: We found suggestive evidence of an association between fine particles and incidence of cerebrovascular events in Europe, even at lower concentrations than set by the current air quality limit value.

Item Type: Article
Authors :
NameEmailORCID
Stafoggia, MUNSPECIFIEDUNSPECIFIED
Cesaroni, GUNSPECIFIEDUNSPECIFIED
Peters, AUNSPECIFIEDUNSPECIFIED
Andersen, ZJUNSPECIFIEDUNSPECIFIED
Badaloni, CUNSPECIFIEDUNSPECIFIED
Beelen, RUNSPECIFIEDUNSPECIFIED
Caracciolo, BUNSPECIFIEDUNSPECIFIED
Cyrys, JUNSPECIFIEDUNSPECIFIED
de Faire, UUNSPECIFIEDUNSPECIFIED
de Hoogh, KUNSPECIFIEDUNSPECIFIED
Eriksen, KTUNSPECIFIEDUNSPECIFIED
Fratiglioni, LUNSPECIFIEDUNSPECIFIED
Galassi, CUNSPECIFIEDUNSPECIFIED
Gigante, BUNSPECIFIEDUNSPECIFIED
Havulinna, ASUNSPECIFIEDUNSPECIFIED
Hennig, FUNSPECIFIEDUNSPECIFIED
Hilding, AUNSPECIFIEDUNSPECIFIED
Hoek, GUNSPECIFIEDUNSPECIFIED
Hoffmann, BUNSPECIFIEDUNSPECIFIED
Houthuijs, DUNSPECIFIEDUNSPECIFIED
Korek, MUNSPECIFIEDUNSPECIFIED
Lanki, TUNSPECIFIEDUNSPECIFIED
Leander, KUNSPECIFIEDUNSPECIFIED
Magnusson, PKUNSPECIFIEDUNSPECIFIED
Meisinger, CUNSPECIFIEDUNSPECIFIED
Migliore, EUNSPECIFIEDUNSPECIFIED
Overvad, KUNSPECIFIEDUNSPECIFIED
Ostenson, CGUNSPECIFIEDUNSPECIFIED
Pedersen, NLUNSPECIFIEDUNSPECIFIED
Pekkanen, JUNSPECIFIEDUNSPECIFIED
Penell, Jj.penell@surrey.ac.ukUNSPECIFIED
Pershagen, GUNSPECIFIEDUNSPECIFIED
Pundt, NUNSPECIFIEDUNSPECIFIED
Pyko, AUNSPECIFIEDUNSPECIFIED
Raaschou-Nielsen, OUNSPECIFIEDUNSPECIFIED
Ranzi, AUNSPECIFIEDUNSPECIFIED
Ricceri, FUNSPECIFIEDUNSPECIFIED
Sacerdote, CUNSPECIFIEDUNSPECIFIED
Swart, WJUNSPECIFIEDUNSPECIFIED
Turunen, AWUNSPECIFIEDUNSPECIFIED
Vineis, PUNSPECIFIEDUNSPECIFIED
Weimar, CUNSPECIFIEDUNSPECIFIED
Weinmayr, GUNSPECIFIEDUNSPECIFIED
Wolf, KUNSPECIFIEDUNSPECIFIED
Brunekreef, BUNSPECIFIEDUNSPECIFIED
Forastiere, FUNSPECIFIEDUNSPECIFIED
Date : September 2014
Identification Number : 10.1289/ehp.1307301
Uncontrolled Keywords : Adult, Aged, Aged, 80 and over, Air Pollutants, Cardiovascular Diseases, Cohort Studies, Environmental Exposure, Europe, Female, Humans, Incidence, Male, Middle Aged, Nitrogen Oxides, Noise, Transportation, Particle Size, Particulate Matter, Regression Analysis, Risk Factors, Stroke
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:18
Last Modified : 17 May 2017 10:18
URI: http://epubs.surrey.ac.uk/id/eprint/827275

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