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Arterial blood pressure and long-term exposure to traffic-related air pollution: an analysis in the European Study of Cohorts for Air Pollution Effects (ESCAPE).

Fuks, KB, Weinmayr, G, Foraster, M, Dratva, J, Hampel, R, Houthuijs, D, Oftedal, B, Oudin, A, Panasevich, S, Penell, J, Sommar, JN, Sørensen, M, Tiittanen, P, Wolf, K, Xun, WW, Aguilera, I, Basagaña, X, Beelen, R, Bots, ML, Brunekreef, B, Bueno-de-Mesquita, HB, Caracciolo, B, Cirach, M, de Faire, U, de Nazelle, A, Eeftens, M, Elosua, R, Erbel, R, Forsberg, B, Fratiglioni, L, Gaspoz, JM, Hilding, A, Jula, A, Korek, M, Krämer, U, Künzli, N, Lanki, T, Leander, K, Magnusson, PK, Marrugat, J, Nieuwenhuijsen, MJ, Ostenson, CG, Pedersen, NL, Pershagen, G, Phuleria, HC, Probst-Hensch, NM, Raaschou-Nielsen, O, Schaffner, E, Schikowski, T, Schindler, C, Schwarze, PE, Søgaard, AJ, Sugiri, D, Swart, WJ, Tsai, MY, Turunen, AW, Vineis, P, Peters, A and Hoffmann, B (2014) Arterial blood pressure and long-term exposure to traffic-related air pollution: an analysis in the European Study of Cohorts for Air Pollution Effects (ESCAPE). Environ Health Perspect, 122 (9). pp. 896-905.

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Abstract

BACKGROUND: Long-term exposure to air pollution has been hypothesized to elevate arterial blood pressure (BP). The existing evidence is scarce and country specific. OBJECTIVES: We investigated the cross-sectional association of long-term traffic-related air pollution with BP and prevalent hypertension in European populations. METHODS: We analyzed 15 population-based cohorts, participating in the European Study of Cohorts for Air Pollution Effects (ESCAPE). We modeled residential exposure to particulate matter and nitrogen oxides with land use regression using a uniform protocol. We assessed traffic exposure with traffic indicator variables. We analyzed systolic and diastolic BP in participants medicated and nonmedicated with BP-lowering medication (BPLM) separately, adjusting for personal and area-level risk factors and environmental noise. Prevalent hypertension was defined as ≥ 140 mmHg systolic BP, or ≥ 90 mmHg diastolic BP, or intake of BPLM. We combined cohort-specific results using random-effects meta-analysis. RESULTS: In the main meta-analysis of 113,926 participants, traffic load on major roads within 100 m of the residence was associated with increased systolic and diastolic BP in nonmedicated participants [0.35 mmHg (95% CI: 0.02, 0.68) and 0.22 mmHg (95% CI: 0.04, 0.40) per 4,000,000 vehicles × m/day, respectively]. The estimated odds ratio (OR) for prevalent hypertension was 1.05 (95% CI: 0.99, 1.11) per 4,000,000 vehicles × m/day. Modeled air pollutants and BP were not clearly associated. CONCLUSIONS: In this first comprehensive meta-analysis of European population-based cohorts, we observed a weak positive association of high residential traffic exposure with BP in nonmedicated participants, and an elevated OR for prevalent hypertension. The relationship of modeled air pollutants with BP was inconsistent.

Item Type: Article
Authors :
NameEmailORCID
Fuks, KBUNSPECIFIEDUNSPECIFIED
Weinmayr, GUNSPECIFIEDUNSPECIFIED
Foraster, MUNSPECIFIEDUNSPECIFIED
Dratva, JUNSPECIFIEDUNSPECIFIED
Hampel, RUNSPECIFIEDUNSPECIFIED
Houthuijs, DUNSPECIFIEDUNSPECIFIED
Oftedal, BUNSPECIFIEDUNSPECIFIED
Oudin, AUNSPECIFIEDUNSPECIFIED
Panasevich, SUNSPECIFIEDUNSPECIFIED
Penell, Jj.penell@surrey.ac.ukUNSPECIFIED
Sommar, JNUNSPECIFIEDUNSPECIFIED
Sørensen, MUNSPECIFIEDUNSPECIFIED
Tiittanen, PUNSPECIFIEDUNSPECIFIED
Wolf, KUNSPECIFIEDUNSPECIFIED
Xun, WWUNSPECIFIEDUNSPECIFIED
Aguilera, IUNSPECIFIEDUNSPECIFIED
Basagaña, XUNSPECIFIEDUNSPECIFIED
Beelen, RUNSPECIFIEDUNSPECIFIED
Bots, MLUNSPECIFIEDUNSPECIFIED
Brunekreef, BUNSPECIFIEDUNSPECIFIED
Bueno-de-Mesquita, HBUNSPECIFIEDUNSPECIFIED
Caracciolo, BUNSPECIFIEDUNSPECIFIED
Cirach, MUNSPECIFIEDUNSPECIFIED
de Faire, UUNSPECIFIEDUNSPECIFIED
de Nazelle, AUNSPECIFIEDUNSPECIFIED
Eeftens, MUNSPECIFIEDUNSPECIFIED
Elosua, RUNSPECIFIEDUNSPECIFIED
Erbel, RUNSPECIFIEDUNSPECIFIED
Forsberg, BUNSPECIFIEDUNSPECIFIED
Fratiglioni, LUNSPECIFIEDUNSPECIFIED
Gaspoz, JMUNSPECIFIEDUNSPECIFIED
Hilding, AUNSPECIFIEDUNSPECIFIED
Jula, AUNSPECIFIEDUNSPECIFIED
Korek, MUNSPECIFIEDUNSPECIFIED
Krämer, UUNSPECIFIEDUNSPECIFIED
Künzli, NUNSPECIFIEDUNSPECIFIED
Lanki, TUNSPECIFIEDUNSPECIFIED
Leander, KUNSPECIFIEDUNSPECIFIED
Magnusson, PKUNSPECIFIEDUNSPECIFIED
Marrugat, JUNSPECIFIEDUNSPECIFIED
Nieuwenhuijsen, MJUNSPECIFIEDUNSPECIFIED
Ostenson, CGUNSPECIFIEDUNSPECIFIED
Pedersen, NLUNSPECIFIEDUNSPECIFIED
Pershagen, GUNSPECIFIEDUNSPECIFIED
Phuleria, HCUNSPECIFIEDUNSPECIFIED
Probst-Hensch, NMUNSPECIFIEDUNSPECIFIED
Raaschou-Nielsen, OUNSPECIFIEDUNSPECIFIED
Schaffner, EUNSPECIFIEDUNSPECIFIED
Schikowski, TUNSPECIFIEDUNSPECIFIED
Schindler, CUNSPECIFIEDUNSPECIFIED
Schwarze, PEUNSPECIFIEDUNSPECIFIED
Søgaard, AJUNSPECIFIEDUNSPECIFIED
Sugiri, DUNSPECIFIEDUNSPECIFIED
Swart, WJUNSPECIFIEDUNSPECIFIED
Tsai, MYUNSPECIFIEDUNSPECIFIED
Turunen, AWUNSPECIFIEDUNSPECIFIED
Vineis, PUNSPECIFIEDUNSPECIFIED
Peters, AUNSPECIFIEDUNSPECIFIED
Hoffmann, BUNSPECIFIEDUNSPECIFIED
Date : September 2014
Identification Number : https://doi.org/10.1289/ehp.1307725
Uncontrolled Keywords : Air Pollutants, Air Pollution, Antihypertensive Agents, Arterial Pressure, Cross-Sectional Studies, Environmental Exposure, Europe, Female, Humans, Hypertension, Male, Nitrogen Oxides, Noise, Transportation, Particulate Matter, Risk Factors, Vehicle Emissions
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:18
Last Modified : 17 May 2017 10:18
URI: http://epubs.surrey.ac.uk/id/eprint/827274

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