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Genetic variation in the CYP2B6 gene is related to circulating 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) concentrations: an observational population-based study.

Penell, J, Lind, L, Fall, T, Syvänen, AC, Axelsson, T, Lundmark, P, Morris, AP, Lindgren, C, Mahajan, A, Salihovic, S, van Bavel, B, Ingelsson, E and Lind, PM (2014) Genetic variation in the CYP2B6 gene is related to circulating 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) concentrations: an observational population-based study. Environ Health, 13 (1).

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Abstract

BACKGROUND: Since human CYP2B6 has been identified as the major CYP enzyme involved in the metabolism of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) and that human 2B6 is a highly polymorphic CYP, with known functional variants, we evaluated if circulating concentrations of a major brominated flame retardant, BDE-47, were related to genetic variation in the CYP2B6 gene in a population sample. METHODS: In the population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (men and women all aged 70), 25 single nucleotide polymorphisms (SNPs) in the CYP2B6 gene were genotyped. Circulating concentrations of BDE-47 were analyzed by high-resolution gas chromatography coupled to high-resolution mass spectrometry (HRGC/ HRMS). RESULTS: Several SNPs in the CYP2B6 gene were associated with circulating concentrations of BDE-47 (P = 10-4 to 10-9). The investigated SNPs came primarily from two haplotypes, although the correlation between the haplotypes was rather high. Conditional analyses adjusting for the SNP with the strongest association with the exposure (rs2014141) did not provide evidence for independent signals. CONCLUSION: Circulating concentrations of BDE-47 were related to genetic variation in the CYP2B6 gene in an elderly population.

Item Type: Article
Authors :
NameEmailORCID
Penell, Jj.penell@surrey.ac.ukUNSPECIFIED
Lind, LUNSPECIFIEDUNSPECIFIED
Fall, TUNSPECIFIEDUNSPECIFIED
Syvänen, ACUNSPECIFIEDUNSPECIFIED
Axelsson, TUNSPECIFIEDUNSPECIFIED
Lundmark, PUNSPECIFIEDUNSPECIFIED
Morris, APUNSPECIFIEDUNSPECIFIED
Lindgren, CUNSPECIFIEDUNSPECIFIED
Mahajan, AUNSPECIFIEDUNSPECIFIED
Salihovic, SUNSPECIFIEDUNSPECIFIED
van Bavel, BUNSPECIFIEDUNSPECIFIED
Ingelsson, EUNSPECIFIEDUNSPECIFIED
Lind, PMUNSPECIFIEDUNSPECIFIED
Date : 2014
Identification Number : https://doi.org/10.1186/1476-069X-13-34
Uncontrolled Keywords : Aged, Aryl Hydrocarbon Hydroxylases, Cytochrome P-450 CYP2B6, Environmental Monitoring, Environmental Pollutants, Female, Halogenated Diphenyl Ethers, Humans, Lipids, Male, Polymorphism, Single Nucleotide, Sweden
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:18
Last Modified : 17 May 2017 10:18
URI: http://epubs.surrey.ac.uk/id/eprint/827273

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