University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Genetic variation in the CYP1A1 gene is related to circulating PCB118 levels in a population-based sample.

Lind, L, Penell, J, Syvänen, AC, Axelsson, T, Ingelsson, E, Morris, AP, Lindgren, C, Salihovic, S, van Bavel, B and Lind, PM (2014) Genetic variation in the CYP1A1 gene is related to circulating PCB118 levels in a population-based sample. Environ Res, 133. pp. 135-140.

Full text not available from this repository.

Abstract

Several of the polychlorinated biphenyls (PCBs), i.e. the dioxin-like PCBs, are known to induce the P450 enzymes CYP1A1, CYP1A2 and CYP1B1 by activating the aryl hydrocarbon receptor (Ah)-receptor. We evaluated if circulating levels of PCBs in a population sample were related to genetic variation in the genes encoding these CYPs. In the population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (1016 subjects all aged 70), 21 SNPs in the CYP1A1, CYP1A2 and CYP1B1 genes were genotyped. Sixteen PCB congeners were analysed by high-resolution chromatography coupled to high-resolution mass spectrometry (HRGC/ HRMS). Of the investigated relationships between SNPs in the CYP1A1, CYP1A2 and CYP1B1 and six PCBs (congeners 118, 126, 156, 169, 170 and 206) that captures >80% of the variation of all PCBs measured, only the relationship between CYP1A1 rs2470893 was significantly related to PCB118 levels following strict adjustment for multiple testing (p=0.00011). However, there were several additional SNPs in the CYP1A2 and CYP1B1 that showed nominally significant associations with PCB118 levels (p-values in the 0.003-0.05 range). Further, several SNPs in the CYP1B1 gene were related to both PCB156 and PCB206 with p-values in the 0.005-0.05 range. Very few associations with p<0.05 were seen for PCB126, PCB169 or PCB170. Genetic variation in the CYP1A1 was related to circulating PCB118 levels in the general elderly population. Genetic variation in CYP1A2 and CYP1B1 might also be associated with other PCBs.

Item Type: Article
Authors :
NameEmailORCID
Lind, LUNSPECIFIEDUNSPECIFIED
Penell, Jj.penell@surrey.ac.ukUNSPECIFIED
Syvänen, ACUNSPECIFIEDUNSPECIFIED
Axelsson, TUNSPECIFIEDUNSPECIFIED
Ingelsson, EUNSPECIFIEDUNSPECIFIED
Morris, APUNSPECIFIEDUNSPECIFIED
Lindgren, CUNSPECIFIEDUNSPECIFIED
Salihovic, SUNSPECIFIEDUNSPECIFIED
van Bavel, BUNSPECIFIEDUNSPECIFIED
Lind, PMUNSPECIFIEDUNSPECIFIED
Date : August 2014
Identification Number : https://doi.org/10.1016/j.envres.2014.05.017
Uncontrolled Keywords : CYP, Epidemiology, Gene, Metabolism, PCB, SNP, Aged, Aryl Hydrocarbon Hydroxylases, Cross-Sectional Studies, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP1A2, Cytochrome P-450 CYP1B1, Female, Genetic Association Studies, Genetic Variation, Genotype, Humans, Male, Polychlorinated Biphenyls, Polymorphism, Single Nucleotide
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:18
Last Modified : 17 May 2017 10:18
URI: http://epubs.surrey.ac.uk/id/eprint/827272

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800