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Correlation between [Na+], [glycosaminoglycan] and Na+/K+ pump density in the extracellular matrix of bovine articular cartilage.

Mobasheri, A (1998) Correlation between [Na+], [glycosaminoglycan] and Na+/K+ pump density in the extracellular matrix of bovine articular cartilage. Physiol Res, 47 (1). pp. 47-52.

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Abstract

The plasma membrane abundance of the Na+/K+ pump or Na+,K+-ATPase depends on the intracellular concentration of Na+ in almost all animal cells. In cartilage, chondrocytes are surrounded by an extracellular matrix which consists of collagen and proteoglycan, a ground substance composed of glycosaminoglycan (GAG) side chains with a high fixed negative charge density. The polyanionic nature of the GAGs tends to draw monovalent cations into the matrix resulting in high [Na+] which may exceed 250 mM. As the concentration of GAGs in the tissue increases, so does [Na+]. In this study, it was found that the density of the Na+/K+ pump, measured by 3H-ouabain binding, correlates with the concentration of GAGs in the tissue. This indicates that chondrocytes are sensitive to their ionic environment and respond to local [Na+] variations by regulating the abundance of the Na+/K+ pump.

Item Type: Article
Authors :
NameEmailORCID
Mobasheri, Aa.mobasheri@surrey.ac.ukUNSPECIFIED
Date : 1998
Uncontrolled Keywords : Animals, Cartilage, Articular, Cattle, Extracellular Matrix, Glycosaminoglycans, Osmolar Concentration, Sodium, Sodium-Potassium-Exchanging ATPase, Tissue Distribution
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:17
Last Modified : 17 May 2017 14:48
URI: http://epubs.surrey.ac.uk/id/eprint/827153

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