University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Regulation of Na+, K+-ATPase density by the extracellular ionic and osmotic environment in bovine articular chondrocytes.

Mobasheri, A (1999) Regulation of Na+, K+-ATPase density by the extracellular ionic and osmotic environment in bovine articular chondrocytes. Physiol Res, 48 (6). pp. 509-512.

Full text not available from this repository.

Abstract

The abundance of Na+, K+-ATPase in cartilage is controlled by the ionic composition of the extracellular environment of chondrocytes, and specifically depends on the local concentration of polyanionic matrix proteoglycans. In this study, it was found that the plasma membrane density of Na+, K+-ATPase in isolated chondrocytes is sensitive to both ionic and osmotic changes in the extracellular environment. The upregulation observed experimentally was similar in magnitude as measured by 3H-ouabain binding, which indicates that chondrocytes respond adaptively to both ionic and osmotic stimuli. The precise mechanism for this novel mode of Na+, K+-ATPase regulation has yet to be elucidated. Physiological perturbation of the ionic and osmotic environment of chondrocytes may alter intracellular Na+ concentration and this may be one of a number of stimuli responsible for alterations to the expression and plasma membrane abundance of Na+, K+-ATPase in the cells.

Item Type: Article
Authors :
NameEmailORCID
Mobasheri, Aa.mobasheri@surrey.ac.ukUNSPECIFIED
Date : 1999
Uncontrolled Keywords : Animals, Cartilage, Articular, Cattle, Cells, Cultured, Chondrocytes, Culture Media, Enzyme Activation, Extracellular Space, Hypertonic Solutions, Isotonic Solutions, Osmotic Pressure, Signal Transduction, Sodium-Potassium-Exchanging ATPase
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:16
Last Modified : 17 May 2017 14:48
URI: http://epubs.surrey.ac.uk/id/eprint/827147

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800