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Integrins and stretch activated ion channels; putative components of functional cell surface mechanoreceptors in articular chondrocytes.

Mobasheri, A, Carter, SD, Martín-Vasallo, P and Shakibaei, M (2002) Integrins and stretch activated ion channels; putative components of functional cell surface mechanoreceptors in articular chondrocytes. Cell Biol Int, 26 (1). pp. 1-18.

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Abstract

Perception of mechanical signals and the biological responses to such stimuli are fundamental properties of load bearing articular cartilage in diarthrodial joints. Chondrocytes utilize mechanical signals to synthesize an extracellular matrix capable of withstanding high loads and shear stresses. Recent studies have shown that chondrocytes undergo changes in shape and volume in a coordinated manner with load induced deformation of the matrix. These matrix changes, together with alterations in hydrostatic pressure, ionic and osmotic composition, interstitial fluid and streaming potentials are, in turn, perceived by chondrocytes. Chondrocyte responses to these stimuli are specific and well coordinated to bring about changes in gene expression, protein synthesis, matrix composition and ultimately biomechanical competence. In this hypothesis paper we propose a chondrocyte mechanoreceptor model incorporating key extracellular matrix macromolecules, integrins, mechanosensitive ion channels, the cytoskeleton and subcellular signal transduction pathways that maintain the chondrocyte phenotype, prevent chondrocyte apoptosis and regulate chondrocyte-specific gene expression.

Item Type: Article
Authors :
NameEmailORCID
Mobasheri, Aa.mobasheri@surrey.ac.ukUNSPECIFIED
Carter, SDUNSPECIFIEDUNSPECIFIED
Martín-Vasallo, PUNSPECIFIEDUNSPECIFIED
Shakibaei, MUNSPECIFIEDUNSPECIFIED
Date : 2002
Identification Number : 10.1006/cbir.2001.0826
Uncontrolled Keywords : Animals, Apoptosis, Calcium, Cartilage, Cell Membrane, Chondrocytes, Cytoskeleton, Gene Expression Regulation, Humans, Integrins, Ion Channels, Kinetics, MAP Kinase Signaling System, Models, Biological, Phenotype, Signal Transduction, Sodium
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:16
Last Modified : 17 May 2017 14:48
URI: http://epubs.surrey.ac.uk/id/eprint/827144

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