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Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9.

Mobasheri, A, Neama, G, Bell, S, Richardson, S and Carter, SD (2002) Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9. Cell Biol Int, 26 (3). pp. 297-300.

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Abstract

Glucose is an important metabolite and a structural precursor for articular cartilage and its transport has significant consequences for cartilage development and functional integrity. In this study the expression of facilitative glucose transporters (GLUTs) in human chondrocytes was investigated. Results showed that at least three GLUT isoforms (GLUT1, GLUT3 and GLUT9) are expressed by normal chondrocytes. Given the central role of glucose in chondrocyte physiology and metabolism, its regular provision via GLUTs will influence the metabolic activity and survival of chondrocytes in cartilage matrices.

Item Type: Article
Authors :
NameEmailORCID
Mobasheri, Aa.mobasheri@surrey.ac.ukUNSPECIFIED
Neama, GUNSPECIFIEDUNSPECIFIED
Bell, SUNSPECIFIEDUNSPECIFIED
Richardson, SUNSPECIFIEDUNSPECIFIED
Carter, SDUNSPECIFIEDUNSPECIFIED
Date : 2002
Identification Number : 10.1006/cbir.2001.0850
Uncontrolled Keywords : Cartilage, Articular, Chondrocytes, Gene Library, Glucose Transport Proteins, Facilitative, Glucose Transporter Type 1, Glucose Transporter Type 3, Humans, Molecular Sequence Data, Monosaccharide Transport Proteins, Nerve Tissue Proteins, Protein Isoforms
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:16
Last Modified : 17 May 2017 14:48
URI: http://epubs.surrey.ac.uk/id/eprint/827142

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