University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Physical activity ameliorates cartilage degeneration in a rat model of aging: a study on lubricin expression.

Musumeci, G, Castrogiovanni, P, Trovato, FM, Imbesi, R, Giunta, S, Szychlinska, MA, Loreto, C, Castorina, S and Mobasheri, A (2015) Physical activity ameliorates cartilage degeneration in a rat model of aging: a study on lubricin expression. Scand J Med Sci Sports, 25 (2). e222-e230.

Full text not available from this repository.


Osteoarthritis (OA) is a common musculoskeletal disorder characterized by slow progression and joint tissue degeneration. Aging is one of the most prominent risk factors for the development and progression of OA. OA is not, however, an inevitable consequence of aging and age-related changes in the joint can be distinguished from those that are the result of joint injury or inflammatory disease. The question that remains is whether OA can be prevented by undertaking regular physical activity. Would moderate physical activity in the elderly cartilage (and lubricin expression) comparable to a sedentary healthy adult? In this study we used physical exercise in healthy young, adult, and aged rats to evaluate the expression of lubricin as a novel biomarker of chondrocyte senescence. Immunohistochemistry and western blotting were used to evaluate the expression of lubricin in articular cartilage, while enzyme-linked immunosorbent assay was used to quantify lubricin in synovial fluid. Morphological evaluation was done by histology to monitor possible tissue alterations. Our data suggest that moderate physical activity and normal mechanical joint loading in elderly rats improve tribology and lubricative properties of articular cartilage, promoting lubricin synthesis and its elevation in synovial fluid, thus preventing cartilage degradation compared with unexercised adult rats.

Item Type: Article
Divisions : Surrey research (other units)
Authors :
Musumeci, G
Castrogiovanni, P
Trovato, FM
Imbesi, R
Giunta, S
Szychlinska, MA
Loreto, C
Castorina, S
Date : April 2015
DOI : 10.1111/sms.12290
Uncontrolled Keywords : Articular cartilage, chondrocyte, joint degeneration, lubricin, osteoarthritis, physical exercise, senescence, Aging, Animals, Biomarkers, Blotting, Western, Cartilage, Articular, Chondrocytes, Glycoproteins, Immunohistochemistry, Male, Motor Activity, Rats, Rats, Wistar, Synovial Fluid
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:16
Last Modified : 24 Jan 2020 18:52

Actions (login required)

View Item View Item


Downloads per month over past year

Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800