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The developing left superior cervical ganglion of Pacas (Agouti paca).

Melo, SR, Nyengaard, JR, da Roza Oliveira, F, Ladd, FV, Abrahão, LM, Machado, MR, Sasahara, TH, de Melo, MP and Ribeiro, AA (2009) The developing left superior cervical ganglion of Pacas (Agouti paca). Anat Rec (Hoboken), 292 (7). pp. 966-975.

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Abstract

In this study the main question investigated was the number and size of both binucleate and mononucleate superior cervical ganglion (SCG) neurons and, whether post-natal development would affect these parameters. Twenty left SCGs from 20 male pacas were used. Four different ages were investigated, that is newborn (4 days), young (45 days), adult (2 years), and aged animals (7 years). By using design-based stereological methods, that is the Cavalieri principle and a physical disector combined with serial sectioning, the total volume of ganglion and total number of mononucleate and binucleate neurons were estimated. Furthermore, the mean perikaryal (somal) volume of mononucleate and binucleate neurons was estimated using the vertical nucleator. The main findings of this study were a 154% increase in the SCG volume, a 95% increase in the total number of mononucleate SCG neurons and a 50% increase in the total volume of SCG neurons. In conclusion, apart from neuron number, different adaptive mechanisms may coexist in the autonomic nervous system to guarantee a functional homeostasis during ageing, which is not always associated with neuron losses.

Item Type: Article
Authors :
NameEmailORCID
Melo, SRUNSPECIFIEDUNSPECIFIED
Nyengaard, JRUNSPECIFIEDUNSPECIFIED
da Roza Oliveira, FUNSPECIFIEDUNSPECIFIED
Ladd, FVUNSPECIFIEDUNSPECIFIED
Abrahão, LMUNSPECIFIEDUNSPECIFIED
Machado, MRUNSPECIFIEDUNSPECIFIED
Sasahara, THUNSPECIFIEDUNSPECIFIED
de Melo, MPUNSPECIFIEDUNSPECIFIED
Ribeiro, AAUNSPECIFIEDUNSPECIFIED
Date : July 2009
Identification Number : https://doi.org/10.1002/ar.20918
Uncontrolled Keywords : Aging, Animals, Autonomic Pathways, Cardiovascular Physiological Phenomena, Cell Count, Cell Nucleus, Cell Proliferation, Cell Size, Functional Laterality, Male, Neurogenesis, Neurons, Rodentia, Species Specificity, Superior Cervical Ganglion, Sympathetic Fibers, Postganglionic
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:14
Last Modified : 17 May 2017 10:14
URI: http://epubs.surrey.ac.uk/id/eprint/826970

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