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Editing of messenger RNA precursors and of tRNAs by adenosine to inosine conversion.

Keller, W, Wolf, J and Gerber, A (1999) Editing of messenger RNA precursors and of tRNAs by adenosine to inosine conversion. FEBS Lett, 452 (1-2). pp. 71-76.

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Abstract

The double-stranded RNA-specific adenosine deaminases ADAR1 and ADAR2 convert adenosine (A) residues to inosine (I) in messenger RNA precursors (pre-mRNA). Their main physiological substrates are pre-mRNAs encoding subunits of ionotropic glutamate receptors or serotonin receptors in the brain. ADAR1 and ADAR2 have similar sequence features, including double-stranded RNA binding domains (dsRBDs) and a deaminase domain. The tRNA-specific adenosine deaminases Tad1p and Tad2p/Tad3p modify A 37 in tRNA-Ala1 of eukaryotes and the first nucleotide of the anticodon (A 34) of several bacterial and eukaryotic tRNAs, respectively. Tad1p is related to ADAR1 and ADAR2 throughout its sequence but lacks dsRBDs. Tad1p could be the ancestor of ADAR1 and ADAR2. The deaminase domains of ADAR1, ADAR2 and Tad1p are very similar and resemble the active site domains of cytosine/cytidine deaminases.

Item Type: Article
Authors :
NameEmailORCID
Keller, WUNSPECIFIEDUNSPECIFIED
Wolf, JUNSPECIFIEDUNSPECIFIED
Gerber, Aa.gerber@surrey.ac.ukUNSPECIFIED
Date : 4 June 1999
Uncontrolled Keywords : Adenosine, Adenosine Deaminase, Amino Acid Sequence, Animals, Base Sequence, Humans, Inosine, Molecular Sequence Data, RNA Editing, RNA Precursors
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:13
Last Modified : 17 May 2017 14:48
URI: http://epubs.surrey.ac.uk/id/eprint/826911

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