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Regulation of glucose transport by nonsteroidal anti-inflammatory drugs

Mobasheri, A, Bondy, CA, Moley, K, Mendes, AF, Rosa, SC, Richardson, SM, Hoyland, JA, Barrett-Jolley, R and Shakibaei, M (2008) Regulation of glucose transport by nonsteroidal anti-inflammatory drugs Advances in Anatomy Embryology and Cell Biology, 200. pp. 50-53.

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Abstract

Cartilage destruction in arthritis and OA is linked to aberrant proinflammatory cytokine and growth factor expression in the joint (Chikanza and Fernandes 2000; Malemud et al. 2003). The proinflammatory cytokines TNF-α and IL-β have been found in significantly elevated levels in the synovial fluid of OA joints (Goldring 1999, 2000a; van den Berg 1999). Catabolic pathways are activated by TNF-α and IL-β, which are both upregulated in OA (Malemud et al. 2003). These proinflammatory mediators cause an increase in cartilage matrix degradation through increased MMP and aggrecanase activity in the joint. In addition, TNF-α and IL-β downregulate ECM protein biosynthesis while concomitantly up-regulating matrix MMP gene and protein expression. When MMPs are activated, cartilage ECM degradation ensues apparently because levels of endogenous cartilage MMP inhibitors cannot regulate MMP activity (Malemud et al. 2003). © 2008 Springer-Verlag Berlin Heidelberg.

Item Type: Article
Authors :
NameEmailORCID
Mobasheri, Aa.mobasheri@surrey.ac.ukUNSPECIFIED
Bondy, CAUNSPECIFIEDUNSPECIFIED
Moley, KUNSPECIFIEDUNSPECIFIED
Mendes, AFUNSPECIFIEDUNSPECIFIED
Rosa, SCUNSPECIFIEDUNSPECIFIED
Richardson, SMUNSPECIFIEDUNSPECIFIED
Hoyland, JAUNSPECIFIEDUNSPECIFIED
Barrett-Jolley, RUNSPECIFIEDUNSPECIFIED
Shakibaei, MUNSPECIFIEDUNSPECIFIED
Date : 10 September 2008
Identification Number : https://doi.org/10.1007/978-3-540-78899-7_8
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:12
Last Modified : 17 May 2017 14:48
URI: http://epubs.surrey.ac.uk/id/eprint/826846

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