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Metabolic dysfunction in arthritis

Mobasheri, A, Bondy, CA, Moley, K, Mendes, AF, Rosa, SC, Richardson, SM, Hoyland, JA, Barrett-Jolley, R and Shakibaei, M (2008) Metabolic dysfunction in arthritis Advances in Anatomy Embryology and Cell Biology, 200. pp. 17-19.

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Abstract

Healthy bones and joints depend on a normally functioning endocrine system. It is a fact of clinical significance that excess IGF-I and growth hormone (GH) causes major joint pathology (Stavrou and Kleinberg 2001). Endocrine disorders not only affect soft connective tissues but also implicate load-bearing musculoskeletal structures including bone, cartilage, synovium, tendon, and ligament. Damage to soft connective tissue and associated innervation is a hallmark of acromegaly, hypothyroidism,and diabetes mellitus (Liote and Orcel 2000). Acromegaly normally presents with quite severe arthritis involving degeneration of the spine and articular cartilage in peripheral joints (Stavrou and Kleinberg 2001). Severe diabetes mellitus increases the risk of neuroarthropathy as a direct result of infection, neuropathy, and vasculopathy. Pituitary tumors can have manifestations similar to rheumatological disease and may cause connective tissue disorders as a result of overproduction or deficiencies of pituitary hormones (Stavrou and Kleinberg 2001). Excessive GH production by the pituitary gland causes cartilage destruction. GH deficiency on the other hand increases the risk of bone fractures. © 2008 Springer-Verlag Berlin Heidelberg.

Item Type: Article
Authors :
NameEmailORCID
Mobasheri, Aa.mobasheri@surrey.ac.ukUNSPECIFIED
Bondy, CAUNSPECIFIEDUNSPECIFIED
Moley, KUNSPECIFIEDUNSPECIFIED
Mendes, AFUNSPECIFIEDUNSPECIFIED
Rosa, SCUNSPECIFIEDUNSPECIFIED
Richardson, SMUNSPECIFIEDUNSPECIFIED
Hoyland, JAUNSPECIFIEDUNSPECIFIED
Barrett-Jolley, RUNSPECIFIEDUNSPECIFIED
Shakibaei, MUNSPECIFIEDUNSPECIFIED
Date : 10 September 2008
Identification Number : https://doi.org/10.1007/978-3-540-78899-7_4
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:12
Last Modified : 17 May 2017 14:48
URI: http://epubs.surrey.ac.uk/id/eprint/826845

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