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Effects of pre- and postnatal protein deprivation and postnatal refeeding on atrial natriuretic peptide (ANP) granules of auricular cardiocytes

Gama, EF, Liberti, EA, Cury, JCS, Coppi, AA and de Souza, RR (2010) Effects of pre- and postnatal protein deprivation and postnatal refeeding on atrial natriuretic peptide (ANP) granules of auricular cardiocytes e-SPEN, 5 (2).

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Abstract

Background &amp; aims: Atrial natriuretic peptide (ANP-granules) of auricular cardiocytes was examined by morphometry in undernourished and refed rats. Methods: The study was conducted on 21 and 42-day-old rats from mothers exposed to 73% protein restriction during the gestation and lactation with and without refeeding and on age-matched control animals. The body and the heart were weighted and the ANP-granules are located by transmission electron microscopy. Results: Protein deprivation in the 42 postnatal days reduced the body weights and the heart weights of the pups. Refeeding did not restore body weight or heart weight to control. In the undernourished group, the number of ANP-granules/field (27.3 ± 6.22) was significantly (p < 0.05) greater at 42 days than in the control (10.5 ± 1.89). In the refed group, the number of ANP-granules was also significantly greater, than that in the group on undernutrition. The diameter of ANP-granules in the undernourished animals was similar to the refed rats at 42 days and significantly greater than in the control (p < 0.05). Conclusion: Refeeding between 21 and 42 days increased the number of ANP-granules and maintained their diameter even when there is a reduction in heart weight caused by protein deprivation. © 2010 European Society for Clinical Nutrition and Metabolism.

Item Type: Article
Authors :
NameEmailORCID
Gama, EFUNSPECIFIEDUNSPECIFIED
Liberti, EAUNSPECIFIEDUNSPECIFIED
Cury, JCSUNSPECIFIEDUNSPECIFIED
Coppi, AAa.coppi@surrey.ac.ukUNSPECIFIED
de Souza, RRUNSPECIFIEDUNSPECIFIED
Date : 1 April 2010
Identification Number : https://doi.org/10.1016/j.eclnm.2010.02.003
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:12
Last Modified : 17 May 2017 14:48
URI: http://epubs.surrey.ac.uk/id/eprint/826833

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