Proteomic identification and profiling of canine lymphoma patients.
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Ratcliffe, L, Mian, S, Slater, K, King, H, Napolitano, M, Aucoin, D and Mobasheri, A (2009) Proteomic identification and profiling of canine lymphoma patients. Vet Comp Oncol, 7 (2). pp. 92-105.
Full text not available from this repository.Abstract
This study employed proteomic and bioinformatic approaches to identify serum biomarkers in canine lymphoma patients. Chilled serum samples derived from non-lymphoma (n = 92) and lymphoma (n = 87) patients were shipped from first opinion veterinary practices, subjected to ion exchange chromatography and analysed by surface-enhanced laser desorption ionization mass spectrometry. Nineteen serum protein peaks were identified between the two groups as being significantly different (P < 0.05) based upon their normalized ion intensities. Two biomarkers were identified that were capable of differentiating lymphoma and non-lymphoma patients. Analysis of the test data provided a positive predictive value (PPV) of 82%. A clinical follow-up study was carried out on 96 canine patients suspected of having lymphoma. Evaluation of this data gave a specificity value of 91%, sensitivity of 75%, PPV of 80% and negative predictive value of 88%. In conclusion, the expression pattern of two serum biomarkers has enabled serum samples to be classified into either lymphoma or non-lymphoma categories.
| Item Type: | Article | ||||||||||||||||||||||||
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| Divisions : | Surrey research (other units) | ||||||||||||||||||||||||
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| Date : | June 2009 | ||||||||||||||||||||||||
| DOI : | 10.1111/j.1476-5829.2009.00165.x | ||||||||||||||||||||||||
| Uncontrolled Keywords : | Age Factors, Animals, Biomarkers, Tumor, Blood Proteins, Case-Control Studies, Diagnosis, Differential, Dog Diseases, Dogs, Lymphoma, Predictive Value of Tests, Proteomics, Sensitivity and Specificity, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | ||||||||||||||||||||||||
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| Depositing User : | Symplectic Elements | ||||||||||||||||||||||||
| Date Deposited : | 17 May 2017 10:12 | ||||||||||||||||||||||||
| Last Modified : | 24 Jan 2020 18:42 | ||||||||||||||||||||||||
| URI: | http://epubs.surrey.ac.uk/id/eprint/826797 |
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