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Expression of the plasma membrane markers aquaporin 1 (AQP1), glucose transporter 1 (GLUT1) and Na, K-ATPase in canine mammary glands and mammary tumours.

Freeman, A, Hetzel, U, Cripps, P and Mobasheri, A (2010) Expression of the plasma membrane markers aquaporin 1 (AQP1), glucose transporter 1 (GLUT1) and Na, K-ATPase in canine mammary glands and mammary tumours. Vet J, 185 (1). pp. 90-93.

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Abstract

This study investigated the expression of the plasma membrane markers aquaporin 1 (AQP1), glucose transporter 1 (GLUT1) and the alpha1 subunit of Na, K-ATPase in normal canine mammary glands and in benign and malignant mammary tumours, using immunohistochemistry and semi-quantitative histomorphometry. AQP1 immunoreactivity was absent from the majority of specimens studied. GLUT1 immunoreactivity was observed in normal mammary tissue and particularly in the epithelial and mesenchymal cells of benign, and in the epithelial cells of malignant tumours, respectively. Na, K-ATPase immunoreactivity was present in normal and neoplastic mammary epithelium and was significantly increased in the epithelium of both benign and malignant tumours. These results suggest that GLUT1 is more highly expressed in neoplastic epithelium and mesenchyme and that Na, K-ATPase is more highly expressed in neoplastic mammary epithelium. In consequence, these membrane proteins may have potential as diagnostic and prognostic biomarkers of canine mammary neoplasia.

Item Type: Article
Authors :
NameEmailORCID
Freeman, AUNSPECIFIEDUNSPECIFIED
Hetzel, UUNSPECIFIEDUNSPECIFIED
Cripps, PUNSPECIFIEDUNSPECIFIED
Mobasheri, Aa.mobasheri@surrey.ac.ukUNSPECIFIED
Date : July 2010
Identification Number : https://doi.org/10.1016/j.tvjl.2010.04.020
Uncontrolled Keywords : Animals, Aquaporin 1, Biomarkers, Dogs, Female, Gene Expression, Glucose Transporter Type 1, Immunohistochemistry, Mammary Glands, Animal, Mammary Neoplasms, Animal, Prognosis, Sodium-Potassium-Exchanging ATPase
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:11
Last Modified : 17 May 2017 14:47
URI: http://epubs.surrey.ac.uk/id/eprint/826778

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