Osteogenic effects of resveratrol in vitro: potential for the prevention and treatment of osteoporosis.

Mobasheri, A and Shakibaei, M (2013) Osteogenic effects of resveratrol in vitro: potential for the prevention and treatment of osteoporosis. Ann N Y Acad Sci, 1290. pp. 59-66.

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Abstract

There are a number of pharmacological agents for the treatment of bone mineral loss and osteoporosis. Hormone replacement therapy (HRT) with estrogen is an established treatment, but it has several adverse side effects and can increase the risk of cancer, heart disease, and stroke. There is increasing interest in nutritional factors and naturally occurring phytochemical compounds with the potential for preventing age-related and postmenopausal bone loss. Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a polyphenolic phytoestrogen with osteogenic and osteoinductive properties. It can modify the metabolism of bone cells and has the capacity to modulate bone turnover. This paper provides an overview of current research on resveratrol and its effects on bone cells in vitro, highlighting the challenges and opportunities facing this area of research, especially in the context of providing nutritional support for postmenopausal women who may not benefit from HRT and older patients with various forms of arthritis, metabolic bone disease, and osteoporosis.

Item Type:	Article
Divisions :	Surrey research (other units)
Authors :	Name Email ORCID Mobasheri, A a.mobasheri@surrey.ac.uk Shakibaei, M
Date :	July 2013
DOI :	10.1111/nyas.12145
Uncontrolled Keywords :	menopause, osteogenesis, osteoporosis, phytoestrogen, resveratrol, Animals, Bone Density, Estrogen Replacement Therapy, Humans, Osteocytes, Osteoporosis, Stilbenes, Treatment Outcome
Related URLs :	Author
Depositing User :	Symplectic Elements
Date Deposited :	17 May 2017 10:11
Last Modified :	24 Jan 2020 18:40
URI:	http://epubs.surrey.ac.uk/id/eprint/826758

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