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3-D technology used to accurately understand equine ileocolonic aganglionosis.

Muniz, E, Lobo Ladd, AA, Lobo Ladd, FV, da Silva, AA, Kmit, FV, Borges, AS, Teixeira, R, da Mota, LS, Belli, CB, de Zoppa, AL, da Silva, LC, de Melo, MP and Coppi, AA (2013) 3-D technology used to accurately understand equine ileocolonic aganglionosis. Cells Tissues Organs, 198 (2). pp. 160-168.

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Abstract

Ileocolonic aganglionosis (ICA) is the congenital and hereditary absence of neurons that constitute the enteric nervous system and has been described in various species including humans - Hirschsprung's disease - and horses - overo lethal white syndrome (OLWS). Hirschsprung's disease affects circa 1 in 5,000 live births. At best, this disease means an inability to absorb nutrients from food (humans). At worse, in horses, it always means death. Despite our general understanding of the functional mechanisms underlying ICA, there is a paucity of reliable quantitative information about the structure of myenteric and submucosal neurons in healthy horses and there are no studies on horses with ICA. In light of these uncertainties, we have used design-based stereology to describe the 3-D structure - total number and true size - of myenteric and submucosal neurons in the ileum of ICA horses. Our study has shown that ICA affects all submucosal neurons and 99% of myenteric neurons. The remaining myenteric neurons (0.56%) atrophy immensely, i.e. 63.8%. We believe this study forms the basis for further research, assessing which subpopulation of myenteric neurons are affected by ileocolonic aganglionosis, and we would like to propose a new nomenclature to distinguish between a complete absence of neurons - aganglionosis - and a weaker form of the disease which we suggest naming 'hypoganglionosis'. Our results are a step forward in understanding this disease structurally.

Item Type: Article
Authors :
NameEmailORCID
Muniz, EUNSPECIFIEDUNSPECIFIED
Lobo Ladd, AAUNSPECIFIEDUNSPECIFIED
Lobo Ladd, FVUNSPECIFIEDUNSPECIFIED
da Silva, AAUNSPECIFIEDUNSPECIFIED
Kmit, FVUNSPECIFIEDUNSPECIFIED
Borges, ASUNSPECIFIEDUNSPECIFIED
Teixeira, RUNSPECIFIEDUNSPECIFIED
da Mota, LSUNSPECIFIEDUNSPECIFIED
Belli, CBUNSPECIFIEDUNSPECIFIED
de Zoppa, ALUNSPECIFIEDUNSPECIFIED
da Silva, LCUNSPECIFIEDUNSPECIFIED
de Melo, MPUNSPECIFIEDUNSPECIFIED
Coppi, AAa.coppi@surrey.ac.ukUNSPECIFIED
Date : 2013
Identification Number : https://doi.org/10.1159/000353218
Uncontrolled Keywords : Animals, Cell Count, Ganglia, Hirschsprung Disease, Horse Diseases, Horses, Ileum, Imaging, Three-Dimensional, Male, Neurons, Organ Size
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:11
Last Modified : 17 May 2017 14:47
URI: http://epubs.surrey.ac.uk/id/eprint/826745

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