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Comprehensive experimental fitness landscape and evolutionary network for small RNA.

Jiménez, JI, Xulvi-Brunet, R, Campbell, GW, Turk-MacLeod, R and Chen, IA (2013) Comprehensive experimental fitness landscape and evolutionary network for small RNA. Proc Natl Acad Sci U S A, 110 (37). pp. 14984-14989.

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Abstract

The origin of life is believed to have progressed through an RNA world, in which RNA acted as both genetic material and functional molecules. The structure of the evolutionary fitness landscape of RNA would determine natural selection for the first functional sequences. Fitness landscapes are the subject of much speculation, but their structure is essentially unknown. Here we describe a comprehensive map of a fitness landscape, exploring nearly all of sequence space, for short RNAs surviving selection in vitro. With the exception of a small evolutionary network, we find that fitness peaks are largely isolated from one another, highlighting the importance of historical contingency and indicating that natural selection would be constrained to local exploration in the RNA world.

Item Type: Article
Authors :
NameEmailORCID
Jiménez, JIUNSPECIFIEDUNSPECIFIED
Xulvi-Brunet, RUNSPECIFIEDUNSPECIFIED
Campbell, GWUNSPECIFIEDUNSPECIFIED
Turk-MacLeod, RUNSPECIFIEDUNSPECIFIED
Chen, IAUNSPECIFIEDUNSPECIFIED
Date : 10 September 2013
Identification Number : 10.1073/pnas.1307604110
Uncontrolled Keywords : Aptamers, Nucleotide, Directed Molecular Evolution, Evolution, Molecular, Models, Genetic, Origin of Life, RNA, Selection, Genetic, Synthetic Biology, Systems Biology
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:11
Last Modified : 17 May 2017 10:11
URI: http://epubs.surrey.ac.uk/id/eprint/826729

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