University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Antibody-mediated neuronal apoptosis: therapeutic implications for prion diseases.

Tayebi, M and Hawke, S (2006) Antibody-mediated neuronal apoptosis: therapeutic implications for prion diseases. Immunol Lett, 105 (2). pp. 123-126.

Full text not available from this repository.

Abstract

Neuronal cell death is considered to be a hallmark in prion diseases. These disorders are believed to result from the post-translational conversion of a normal cell membrane sialoglycoprotein PrPC, composed primarily of alpha-helical structure, into a disease specific isoform, PrPSc that is rich in beta-sheet and partially proteinase-resistant. Recent in vivo studies indicate that prion replication can be inhibited by anti-PrP monoclonal antibodies that led to the indefinite delay in the development of prion disease. The recent report by Solforosi and colleagues has increased the need to understand pathway(s) leading to prion-associated apoptosis and neuronal death thought to be the cause of death in transmissible spongiform encephalopathy (TSE) individuals. Furthermore, these reports increased momentum about the use of antibody-based therapy in prion diseases, although great caution should be exerted when using anti-prion antibodies directly into the central nervous system (CNS) with special emphasis on refined strategies such as specific targeting of regions of the prion protein thought not to be involved in signalling pathways.

Item Type: Article
Authors :
NameEmailORCID
Tayebi, Mm.tayebi@surrey.ac.ukUNSPECIFIED
Hawke, SUNSPECIFIEDUNSPECIFIED
Date : 15 June 2006
Identification Number : 10.1016/j.imlet.2006.03.001
Uncontrolled Keywords : Animals, Antibodies, Apoptosis, Humans, Immunotherapy, Neurons, Prion Diseases, Prions
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:09
Last Modified : 17 May 2017 14:47
URI: http://epubs.surrey.ac.uk/id/eprint/826649

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800