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Unswitched immunoglobulin M response prolongs mouse survival in prion disease.

Tayebi, M, Collinge, J and Hawke, S (2009) Unswitched immunoglobulin M response prolongs mouse survival in prion disease. J Gen Virol, 90 (Pt 3). pp. 777-782.

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Several studies have failed to demonstrate the presence of immune responses to infectious prions during the course of prion disease, reflecting the identical primary structure of normal and disease-associated isoforms and the widespread expression of the normal cellular form of prion protein, PrP(C), leading to B- and/or T-cell tolerance of disease-associated isoforms and also possibly because antigen-presenting cells are unable to process the highly aggregated, detergent-insoluble, protease-resistant form, PrP(Sc). Under certain circumstances, PrP(Sc) can be revealed to the immune system in immunogenic form, and it has been shown previously that anti-PrP antibodies can be induced to prions immunoadsorbed to Dynabeads using specific anti-PrP monoclonal antibodies, even in PrP-sufficient mice. This study demonstrated in a murine scrapie model that PrP-Dynabeads effectively stimulated the immune system to produce anti-PrP IgM antibodies over prolonged periods after repeated immunization. It was also shown that these immune responses prolonged incubation times in murine scrapie.

Item Type: Article
Divisions : Surrey research (other units)
Authors :
Collinge, J
Hawke, S
Date : March 2009
DOI : 10.1099/vir.0.005041-0
Uncontrolled Keywords : Animals, Antibodies, Monoclonal, Female, Immunization, Immunoglobulin M, Immunomagnetic Separation, Mice, PrPSc Proteins, Prion Diseases, Scrapie
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:09
Last Modified : 24 Jan 2020 18:36

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