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Immunohistochemical and ultrastructural evidence of hog cholera virus infection of megakaryocytes in bone marrow and spleen.

Gómez-Villamandos, JC, Ruiz-Villamor, E, Salguero, FJ, Bautista, MJ, Carrasco, L, Sánchez, C, Quezada, M and Sierra, MA (1998) Immunohistochemical and ultrastructural evidence of hog cholera virus infection of megakaryocytes in bone marrow and spleen. J Comp Pathol, 119 (2). pp. 111-119.

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Abstract

Twelve pigs were inoculated with a highly virulent strain of hog cholera virus (HCV) to study viral infection of megakaryocytes in the bone marrow and spleen. Immunohistochemical and ultrastructural examination revealed HCV infection in a small proportion (2.5-9.0%) of these cells from the 2nd to the 9th day after inoculation, at which time the experiment was terminated. Megakaryocyte infection accounts for the presence of viral antigens in platelets. The latter may represent a passive vehicle for spreading the virus in the animal.

Item Type: Article
Authors :
NameEmailORCID
Gómez-Villamandos, JCUNSPECIFIEDUNSPECIFIED
Ruiz-Villamor, EUNSPECIFIEDUNSPECIFIED
Salguero, FJUNSPECIFIEDUNSPECIFIED
Bautista, MJUNSPECIFIEDUNSPECIFIED
Carrasco, LUNSPECIFIEDUNSPECIFIED
Sánchez, CUNSPECIFIEDUNSPECIFIED
Quezada, MUNSPECIFIEDUNSPECIFIED
Sierra, MAUNSPECIFIEDUNSPECIFIED
Date : August 1998
Uncontrolled Keywords : Animals, Antigens, Viral, Bone Marrow, Cell Count, Classical Swine Fever, Classical swine fever virus, Female, Immunoenzyme Techniques, Inclusion Bodies, Male, Megakaryocytes, Platelet Count, Spleen, Swine
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:09
Last Modified : 17 May 2017 10:09
URI: http://epubs.surrey.ac.uk/id/eprint/826586

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