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Classical swine fever: morphological and morphometrical study of pulmonary intravascular macrophages.

Carrasco, L, Ruiz-Villamor, E, Gómez-Villamandos, JC, Salguero, FJ, Bautista, MJ, Maciá, M, Quezada, M and Jover, A (2001) Classical swine fever: morphological and morphometrical study of pulmonary intravascular macrophages. J Comp Pathol, 125 (1). pp. 1-7.

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Abstract

To gain further insight into the pathogenesis of classical swine fever (CSF), the changes induced by hog cholera (HC) virus in pulmonary intravascular macrophages (PIMs) were examined. Twelve pigs were inoculated by the intramuscular route with a virulent strain of HC virus (Quillota strain) and killed in groups of three at 4, 7, 10 and 14 days post-inoculation. Immunohistochemical and ultrastructural examination revealed HC virus infection in endothelial cells, PIMs, and interstitial and alveolar macrophages. In addition to viral replication, a predominant feature was the secretory activation of PIMs, characterized by expanded rough endoplasmic reticulum and hyperplastic Golgi complexes. The results obtained suggest that macrophage activation and the subsequent release of pro-inflammatory mediators play an important role in the pathogenesis of CSF.

Item Type: Article
Authors :
NameEmailORCID
Carrasco, LUNSPECIFIEDUNSPECIFIED
Ruiz-Villamor, EUNSPECIFIEDUNSPECIFIED
Gómez-Villamandos, JCUNSPECIFIEDUNSPECIFIED
Salguero, FJUNSPECIFIEDUNSPECIFIED
Bautista, MJUNSPECIFIEDUNSPECIFIED
Maciá, MUNSPECIFIEDUNSPECIFIED
Quezada, MUNSPECIFIEDUNSPECIFIED
Jover, AUNSPECIFIEDUNSPECIFIED
Date : July 2001
Identification Number : https://doi.org/10.1053/jcpa.2001.0470
Uncontrolled Keywords : Animals, Cell Count, Classical Swine Fever, Classical swine fever virus, Endothelium, Vascular, Female, Immunoenzyme Techniques, Lung, Macrophages, Alveolar, Male, Microscopy, Electron, Organelles, Swine, Viral Envelope Proteins
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:09
Last Modified : 17 May 2017 10:09
URI: http://epubs.surrey.ac.uk/id/eprint/826583

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