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Morphological and immunohistochemical changes in splenic macrophages of pigs infected with classical swine fever.

Gómez-Villamandos, JC, Ruiz-Villamor, E, Bautista, MJ, Sánchez, CP, Sánchez-Cordón, PJ, Salguero, FJ and Jover, A (2001) Morphological and immunohistochemical changes in splenic macrophages of pigs infected with classical swine fever. J Comp Pathol, 125 (2-3). pp. 98-109.

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Abstract

Classical swine fever (CSF) was induced in 20 pigs by inoculation with a virulent strain of CSF virus to determine sequential changes (2, 4, 7, 10 and 14 days post-inoculation) in the number and morphology of splenic macrophages (red pulp and lymphoid marginal zone) and thus to assess the role of these cells in the pathogenesis of the disease. The first splenic cells to be infected with CSF virus were macrophages in the marginal zone followed by other macrophage populations. The initial phase of CSF was associated with an increase in splenic macrophage numbers in the marginal zone and a decrease in the red pulp. Subsequently, the numbers in the red pulp increased. The study suggested that infection, mobilization and apoptosis of splenic macrophages play an important role in the spread of CSF virus in vivo. Moreover, the secretory changes that occurred in macrophages in the initial phase of the infection suggested that macrophages release chemical mediators capable of modulating pathogenesis.

Item Type: Article
Authors :
NameEmailORCID
Gómez-Villamandos, JCUNSPECIFIEDUNSPECIFIED
Ruiz-Villamor, EUNSPECIFIEDUNSPECIFIED
Bautista, MJUNSPECIFIEDUNSPECIFIED
Sánchez, CPUNSPECIFIEDUNSPECIFIED
Sánchez-Cordón, PJUNSPECIFIEDUNSPECIFIED
Salguero, FJUNSPECIFIEDUNSPECIFIED
Jover, AUNSPECIFIEDUNSPECIFIED
Date : August 2001
Identification Number : https://doi.org/10.1053/jcpa.2001.0487
Uncontrolled Keywords : Animals, Antigens, Viral, Biomarkers, Cell Count, Classical Swine Fever, Classical swine fever virus, Cytoplasmic Vesicles, Female, Immunoenzyme Techniques, Inclusion Bodies, Viral, Macrophages, Male, Spleen, Time Factors
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:09
Last Modified : 17 May 2017 10:09
URI: http://epubs.surrey.ac.uk/id/eprint/826582

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